Prof. Dr. med. Markus Hufnagel, DTM&H

Dr. Markus HufnagelDr. Markus Hufnagel is a specialist in pediatric and adolescent medicine, infectious diseases, pediatric rheumatology, immunology, tropical medicine, travel medicine and vaccinology. As Director of Pediatric Rheumatology and Pediatric Infectious Diseases at the University Children's Hospital in Freiburg, Germany, Dr. Hufnagel is responsible for patient care and care management, medical teaching and medical research. His current research focuses on antibiotic usage and resistance, epidemiology of COVID-19, infections with gram-positive pathogens, medical care of refugees and quality of care of pediatric rheumatology patients. Active in numerous international projects, Dr. Hufnagel regularly collaborates with European and North American partners, as well as with several NGOs working in resource-poor countries.

Professional Experience

Curriculum vitae

 

At present

  • Professor of Pediatric and Adolescent Medicine (since 2016)
  • Director of Pediatric Rheumatology and Pediatric Infectious Diseases (since 2023)
  • Attending Physician ("Oberarzt" since 2010)
  • Infectious Diseases Specialist (Board Certified as of 2009)
  • Pediatric Rheumatologist (Board Certified as of 2010)
  • Immunologist (Board Certified as of 2021)
  • Lecturer in Pediatric Infectious Diseases, Tropical Medicine, Travel Medicine, Vaccinology, Immunology and Rheumatology (since 2005)
    University Children’s Hospital, Freiburg, Germany

2010 – 2012

  • Attending Physician ("Oberarzt" since 2010)
  • Director of Pediatric Rheumatology and Deputy Director of Pediatric Infectious Diseases (2010 – 2022)
  • Director of Pediatric Outpatient Clinic (2010 – 2012)
    University Children’s Hospital, Freiburg, Germany

2009

2007 – 2008

Apr – May 2007

2005 – 2007

2003 – 2005

2000 – 2003

1995 – 2000

1994

1992 – 1994


International Visiting Lectureships

 

Sept - Oct 2022

Nov 2014

Sept - Oct 2013

Nov 2011

July 2011

Mar 2010

Dec 2008


Training

Education, Training & Degrees

 

2021
  • Board Certification as Immunologist ("Zusatzweiterbildung")
2018
2016
2010
  • Board Certification as Pediatric Rheumatologist ("Zusatzweiterbildung")
2009
  • Board Certification as Physician for Infectious Diseases ("Zusatzweiterbildung")
2009
  • Certification of PhD Degree Equivalency and Associate Professor Status, PhD in Bacterial Immunology (in accordance with official U.S. guidelines)
2009
2009, 2013
2016 & 2021
  • Good Clinical Practice (GCP) Training Certification, Mainz, Germany
    (Initial certification followed by recertification in subsequent years)
2007

2005

  • Board Certification as Physician for Pediatrics and Adolescent Medicine ("Facharzt")

1995

1994

1994

  • Medical License ("Approbation als Arzt")

1992

  • Medical Certification ("Medizinisches Staatsexamen")

1984 – 1992

  • Medical School, Study of Human Medicine
    – Friedrich-Alexander University, Erlangen, Germany
    – Albert-Ludwig University, Freiburg, Germany
    – University of Basel, Basel, Switzerland
    – University of Cape Town, Cape Town, South Africa

Affiliations

Professional Memberships

 

DGKJ
DGPI
GKJR
ATP
ESPID
AGPRS

Grants, Fellowships & Awards

 

2022

2014

2013

2011

2011

2010

2008

2005

1999


Publications

Original Research

 

Freudenhammer M, Minden K, Arbogast M, Leschka SC, Hufnagel M (2023).
Therapy-refractory course of extended-oligoarticular juvenile idiopathic arthritis.
[Therapierefraktärer Verlauf einer extended-oligoartikulären juvenilen idiopathischen Arthritis.]

Arthritis + Rheuma 43:275-8. DOI: 10.1055/a-2121-6546. German.
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Papan C, Reifenrath K, Last K, Attarbaschi Andishe A, Graf N, Groll AH, Hübner J, Laws HJ, Lehrnbecher T, Liese JG, Martin L, Tenenbaum T, Vieth S, von Both U, Wagenpfeil G, Weichert S, Hufnagel M, Simon A (2023).
Antimicrobial use in pediatric oncology and hematology: a cross-sectional, multi-center point-prevalence study with a multi-step qualitative adjudication process.
Lancet Regional Health - Europe; DOI: 10.1016/j.lanepe.2023.100599
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Brunner HI, Foeldvari I, Alexeeva E, Ayaz NA, Calvo Penades I, Kasapcopur O, Chasnyk VG, Hufnagel M, Zuber Z, Schulert GS, Ozen S, Rakhimyanova A, Ramanan A, Scott C, Sozeri B, Zholobova E, Martin R, Zhu X, Whelan S, Pricop L, Martini A, Lovell DJ and Ruperto N, on behalf of Paediatric Rheumatology INternational Trials Organization (PRINTO) and Pediatric Rheumatology Collaborative Study Group (PRCSG) (2023).
Secukinumab in enthesitis-related arthritis and juvenile psoriatic arthritis: a randomised, double-blind, placebo-controlled, treatment withdrawal, phase 3 trial.
Annals of Rheumatic Diseases 82:154-60. DOI: 10.1136/ard-2022-222849
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Lohrmann F, Hufnagel M, Kunze M, Afshar B, Creti R, Detcheva A, Kozakova J, Rodriguez-Granger J, Skov Sørensen UB, Margarit I, Maione D, Rinaudo D, Orefici G, Telford J, de la Rosa Fraile M, Kilian M, Efstratiou A, Berner R, Melin P, for the DEVANI study group (2022).
Neonatal invasive disease caused by Streptococcus agalactiae in Europe: the DEVANI multi-center study.
Infection (Online ahead of print). DOI: 10.1007/s15010-022-01965-x
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Broehaert IJ, Klein A, Windschall D, Rogalski B, Weller-Heinemann F, Oommen P, Küster M, Foeldvari I, Minden K, Hospach A, Hufnagel M, Berger T, Geikowski T, Quietzsch J, Horneff G (2022).
Development of inflammatory bowel disease in children with juvenile idiopathic arthritis treated with biologics.
Journal of Pediatric Gastroenterology and Nutrition, (online ahead of print). DOI: 10.1097/MPG.0000000000003656
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Papan C, Reifenrath K, Last K, Attarbaschi A, Graf N, Groll AH, Hübner J, Laws HJ, Lehrnbecher T, Liese J, Martin L, Tenenbaum T, Weichert S, Vieth S, von Both U, Hufnagel M, Simon A, for the Study Group “Antibiotic Stewardship” of the DGPI and the Study Group “Febrile Neutropenia” of the GPOH (2022).
Study protocol for a multi-center point-prevalence study with qualitative expert panel assessment of antimicrobial use in pediatric oncology and hematology.
JMIR Research Protocols 11:e35774
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Sorg AL, Bergfeld L, Jank M, Corman V, Semmler I, Görtz A, Beyerlein A, Verjans E, Wagner N, von Bernuth H, Lander F, Weil K, Hufnagel M, Spiekerkoetter U, Cho-Ming C, Nährlich L, Muntau AC, Schulze-Sturm U, Hansen G, Wetzke M, Jung AM, Niehues T, Fricke-Otto S, von Both U, Huebner J, Behrends U, Liese JG, Schwerk C, Drosten C, von Kries R, Schroten H (2022).
Cross-sectional seroprevalence surveys of SARS-CoV-2 antibodies in children in Germany, June 2020 to May 2021.
Nature Communications, 13, 3128 (2022). DOI: 0.1038/s41467-022-30482-6
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Reiser C, Klotsche J, Hospach T, Berendes R, Schnabel A, Jansson A, Hufnagel M, Groesch N, Niewerth M, Minden K, Girschick H (2021).
First year follow-up of children with chronic non-bacterial osteomyelitis – and analysis of the German National Pediatric Rheumatologic Database 2009-2018.
Arthritis Research & Therapy, 23:281.
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Jakob A, Hufnagel M (2021).
Follow-up on Children with PIMS. [Nachsorge von Kindern mit PIMS].
Deutsches Ärzteblatt, 118:A1814-1816. German.
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Geweniger A, Janda A, Eder K, Fressle R, Kannan CV, Fahnenstich H, Elze M, Müller C, Henneke P, Hufnagel M, Elling R (2021).
High diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of pediatric pulmonary tuberculosis.
BMC Infectious Diseases, 21:946.
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Cook A, Sharland M, Yau Y, PediBSI Group, Bielicki J (2021).
Improving empiric antibiotic prescribing in pediatric bloodstream infections: a potential application of weighted-incidence syndromic combination antibiograms (WISCA).
Expert Reviews of Anti-Infective Therapy. DOI: 10.1080/14787210.2021.1967145 (published online 15 Sept. 2021) .
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Bemtgen X, Klingel K, Hufnagel M, Janda A, Bode C, Staudacher DL, Supady A, Jandova I (2021).
Case report: Lymphohistiocytic myocarditis with severe cardiogenic shock requiring mechanical cardiocirculatory support in Multisystem Inflammatory Syndrome following SARS-CoV-2 infection.
Frontiers in Cardiovascular Medicine, 8:716198.
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Holstiege J, Bätzing J, Akmatov MK, Tillmann R, Hufnagel M, Hübner J, Berner R, Simon A (2021).
Reduction of outpatient antibiotic prescriptions for children and adolescents in Germany 2010-2019. Regional development in the German statuatory health insurance regions. [Rückgang der ambulanten Antibiotikaverordnungen bei Kindern und Jugendlichen in Deutschland 2010-2019. Regionale Entwicklung in den deutschen KV-Regionen.]
Monatsschrift Kinderheilkunde (published online 30 July 2021). German.
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Kohns Vasconcelos M, Loens K, Sigfrid L, Iosifidis E, Epalza C, Dona D, Papachristou S, Roilides E, Gijon M, Rojo P, Minotti C, Da Dalt L, Islam S, Jarvis J, Syggelou A, Tsolia M, Nyirenda Nyang’wa M, Keers S, Renk H, Gemmel AL, D’Amore C, Ciofi degli Atti M, Rodriguez-Tenreiro Sanchez C, Martinon-Torres F, Burokiene S, Goetghebuer T, Spoulou V, Riordan A, Calvo C, Gkentzi D, Hufnagel M, Openshaw P, Goossens H, Leven G, Fraaij P, Giaquinto C, Bielicki JA, Horby P, Sharland M (2021).
Aetiology of acute respiratory tract infection in pre-school children requiring hospitalisation in Europe – results from the PED-MERMAIDS multi-centre case-control study.
BMJ Open Respiratory Research, 8:e000887.
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Lohrmann F, Berg A, Wicker E, Imm A, Krause G, Zürn K, Berner R, Hufnagel M, Lander F (2021).
Prevalence of Capsular Serotype, Pilus Island Distribution, and Antibiotic Resistance in Pediatric and Adult Invasive Group B Streptococcus Isolates: Data From a Nationwide Prospective Surveillance Study in Germany.
Pediatric Infectious Diseases, 40:76-82, (published online 16 Nov 2020).
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Kohns Vasconcelos M, Renk H, Popielska J, Nyirenda Nyang’wa M, Burokiene S, Gkentzi D, Gowin E, Donà D, Villanueva-Medina S, Riordan A, Hufnagel M, Eisen S, Da Dalt L, Giaquinto C, Bielicki JA (2021).
SARS-CoV-2 testing and infection control strategies in European paediatric emergency departments during the first wave of the pandemic.
European Journal of Pediatrics, 180:1299-1305.
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Ruperto N, Brunner H, Ramanan A, Horneff G, Cuttica R, Henrickson M, Lopez JA, Boteanu AL, Calvo Penades I, Minden K, Schmeling H, Hufnagel M, Weiss JE, Pardeo M, Nanda A, Roth J, Rubio-Perez N, Hsu JC, Wimalasundera S, Wells C, Bharucha K, Douglass W, Bao M, Mallalieu NL, Martini A, Lovell D, De Benedetti F for the Paediatric Rheumatology International Trial Organization (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG) (2021).
Subcutaneous dosing regimen of tocilizumab in children with systemic or polyarticular juvenile idiopathic arthritis.
Rheumatology, 60:4568-4580.
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Quartier P, Alexeeva E, Tamàs C, Chasnyk V, Wulffraat N, Palmblad K, Wouters C, Brunner H, Marzan K, Schneider R, Horneff G, Martini A, Anton J, Wei X, Slade A, Ruperto N, Abrams K; Pediatric Rheumatology International Trials Organization (PRINTO), the Pediatric Rheumatology Collaborative Study Group (PRCSG) (2021).
(* Dr. Markus Hufnagel is a contributing member of the PRINTO Study Group.)
Tapering Canakinumab Monotherapy in Patients with Systemic Juvenile Idiopathic Arthritis in Clinical Remission: Results from an Open-label, Randomized Phase IIIb/IV Study.
Arthritis Rheumatology 73:336-346.
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Jakob A, Schachinger E, Klau S, Hufnagel M, van der Werf Grohmann N, Stiller B, Lehner A, Ulrich S (2020).
Evaluation of serum osteopontin levels as biomarkers for children with Kawasaki disease.
Annals of Cardiology and Vascular Medicine, 3:1035.
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Walser M, Hermann M, Hufnagel M, Haas NA, Fischer M, Dalla-Pozza R, Jakob A (2020).
Anakinra and etanercept combination treatment in a child with severe, non-responsive Kawasaki disease.
Pediatric Infectious Diseases Journal 39:e310-e313.
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Armann J, Diffloth N, Simon A, Doenhardt M, Hufnagel M, Trotter A, Schneider DT, Hübner J, Berner J (2020).
Hospital admission in children and adolescents with COVID-19—early results from a national survey conducted by the German Society for Pediatric Infectious Diseases (DGPI). [Hospitalisierungen von Kindern und Jugendlichen mit COVID-19 – erste Ergebnisse eines deutschlandweiten Surveys der deutschen Gesellschaft für Pädiatrische Infektiologie (DGPI)].
Deutsches Ärzteblatt 117:373-374. German.
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Zürn K, Lander F, Hufnagel M, Monecke S, Berner R (2020).
Microarray analysis of Group B streptococci causing invasive neonatal early- and late-onset infection.
Pediatric Infectious Diseases Journal 39:449-453.
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Janda A, Eder K, Fressle R, Geweniger A, Diffloth N, Heeg M, Binder N, Sitaru A, Rohr J, Henneke P, Hufnagel M, Elling R. (2020).
Comprehensive infectious disease screening in a cohort of unaccompanied refugee minors in Germany from 2016 to 2017: A cross-sectional study.
PLoS Medicine, 17(3): e1003076.
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Kuntz M, Kohlfürst DS, Feiterna-Sperling C, Krüger R, Baumann U, Buchtala L, Elling R, Grote V, Hübner J, Hufnagel M, Kaiser-Labusch P, Liese J, Otto EM, Rose MA, Schneider C, Schuster V, Seidl M, Sommerburg O, Vogel M, von Bernuth H, Weiß M, Zimmermann T, Nieters A, Zenz W, and Henneke P for the NTMkids consortium (2020).
Season, sex and surgery: Risk factors for complicated lymphadenitis caused by non-tuberculous mycobacteria in children.
Emerging Infectious Diseases 26:579-586.
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Klein A, Klotsche J, Hügle B, Minden K, Hospach A, Weller-Heinemann F, Schwarz T, Dressler F, Trauzeddel R, Hufnagel M, Foeldvari I, Borte M, Kuemmerle-Deschner J, Brunner J, Oommen PT, Föll D, Tenbrock K, Urban A, Horneff G (2020).
Long-term surveillance of biologic therapies in systemic-onset juvenile idiopathic arthritis. Data from the German BIKER registry.
Rheumatology 59:2287-2298.
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Konrad P, Hufnagel M, Berner R, Töpfner N (2020).
Long-term, single-center surveillance of non-invasive group A streptococcal (GAS) infections, emm types and emm clusters.
European Journal of Clinical Microbiology and Infectious Diseases 39:273-280.
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Bélard S, Brand J, Schulze-Sturm U, Janda A, von Both U, Tacoli C, Alberer M, Kempf C, Stegemann MS, Krüger R, Varnholt V, Blohm M, Reiter K, Zoller T, Suttorp N, Mall M, von Bernuth H, Gratopp A, Hübner J, Hufnagel M, Kobbe R, Kurth F (2019).
Intravenous Artesunate for Imported Severe Malaria in Children Treated in Four Tertiary Care Centers in Germany: A Retrospective Study.
Pediatric Infectious Diseases Journal 38:e295-e300.
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Elling R, Böttcher S, du Bois F, Müller A, Prifert C, Weissbrich B, Hofmann J, Korn K, Eis-Hübinger A-M, Hufnagel M, Panning M (2019).
Epidemiology of Human Parechovirus Type 3 Upsurge in 2 Hospitals, Freiburg, Germany, 2018.
Emerging Infectious Diseases 25:1384-1388.
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Hsia Y, Lee BR, Versporten A, Yang Y, Bielicki J, Jackson C, Newland J, Goossens H, Magrini N, Sharland M on behalf of the GARPEC and Global-PPS networks (2019).
*Dr. Hufnagel is a contributing member of the GARPEC and Global-PPS networks.
Using the WHO Access/Watch/Reserve classification to define patterns of hospital antibiotic use: analysis of pediatric point prevalence survey data from 56 countries. The first AWaRe PPS.
Lancet Global Health 7:e861-871.
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Brunner HI, Holland MJ, Beresford MW, Ardoin SP, Appenzeller S, Silva CA, Flores F, Goilav B, Avar Aydin PO, Wenderfer SE, Levy DM, Ravelli A, Khubchandani R, Avcin T, Klein-Gitelman MS, Ruperto N, Feldman BM, Ying J; Paediatric Rheumatology International Trial Organisation and Pediatric Rheumatology Collaborative Study Group (2019)
*Dr. Hufnagel is a contributing member of the Paediatric Rheumatology International Trial Organization.
American College of Rheumatology Provisional Criteria for Clinically Relevant Improvement in Children and Adolescents With Childhood-Onset Systemic Lupus Erythematosus.
Arthritis Care Res 71:579-90.
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Meyer K, Volkmann A, Hufnagel M, Schachinger E, Klau S, Horstmann J, Berner R, Fischer M, Lehner A, Haas N, Ulrich S, Jakob A (2019)
Breastfeeding and vitamin D supplementation reduce the risk of Kawasaki disease in a German population-based case-control study.
BMC Pediatrics. 2019 Feb 26;19(1):66.
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Wicker E, Lander F, Weidemann F, Hufnagel M, Berner R, Krause G (2019)
Group B Streptococci: Declining Incidence in Infants in Germany.
Pediatric Infectious Diseases Journal. 38:516-519.
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Lehrnbecher T, Groll AH, Agyeman P, Amman RA, Attarbaschi A, Behrends U, Berger C, Hamprecht A, Hufnagel M, Laws HJ, Scheler M, Temme C, Vieth S, Simon A für die Arbeitsgemeinschaften “Infektionen” der GPOH und “Fieber bei Neutropenie” der DGPI (2018)
Recommendations for Diagnostics and Therapy of Children with Cancer Presenting with Fever and Neutropenia - Comparison of Two Current Guidelines. [Empfehlungen zur Diagnostik und Therapie bei krebskranken Kindern mit Fieber und Granulozytopenie - Vergleich zweier aktueller Leitlinien].
Klinische Pädiatrie. 230:115-121. German.
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Hufnagel M, Versporten A, Bielicki J, Drapier N, Sharland M, Goossens H, for the ARPEC Project Group (2018)
High rates of prescribing for prophylaxis in children and neonates: Results from the Antibiotic Resistance and Prescribing in European Children Point Prevalance Survey (ARPEC-PPS).
Journal of the Pediatriatric Infectious Disease Society. 8:143-151.
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Pschibul A, Janzarik WG, Franck P, Hufnagel M, Beck C, Korinthenberg R (2018)
Cystic encephalomalacia following vasculopathy and vasospasm of proximal intracranial arteries due to pneumococcal meningitis in a young infant.
Neuropediatrics. 49:213-216.
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Jakob A, von Kries R, Horstmann J, Hufnagel M, Stiller B, Berner R, Schachinger E, Meyer K, Obermeier V (2018)
Failure to predict high risk Kawasaki disease patients in a population-based study cohort in Germany.
Pediatric Infectious Disease Journal. 37:850-855.
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Schwarz T, Oommen PT, Windschall D, Weissbarth-Riedel E, Trauzeddel R, Grote V, von Bismarck P, Morbach H, Hofmann C, Holl-Wieden A, Hügle B, Schnabel A, Dedeoglu F, Ferguson PJ, Zhao Y, Borte M, Haas JP, Hufnagel M, Hedrich CM, Girschick HJ, Jansson AF für die PRO-KIND CNO-Projektgruppe (2018)
Protocols for classification, monitoring and therapy in pediatric rheumatology (PRO-KIND): Chronic non-bacterial osteomyelitis (CNO). [HarmProtokolle zur Klassifikation, Überwachung und Therapie in der Kinderrheumatologie (PRO-KIND): Chronisch nicht-bakterielle Osteomyelitis (CNO)].
Arthritis + Rheuma 38:282-288. German.
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Hinze CH, Holzinger D, Lainka E, Haas JP, Speth F, Kallinich T, Rieber N, Hufnagel M, Jansson A, Hedrich C, Winowski H, Berger T, Foeldvari I, Ganser G, Hospach T, Huppertz H-I, Mönkemöller K, Neudorf U, Weißbarth-Riedel E, Wittkowski H, Horneff G, Foell D; PRO-KIND SJIA project (2018)
Practice and consensus-based diagnostic strategies in diagnosing and managing systemic juvenile idiopathic arthritis in Germany.
Pediatric Rheumatology Online Journal 16:7.
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Ingegnoli F, Ughi N, Dinsdale G, Orenti A, Boracchi P, Allanore Y, Foeldvari I, Sulli A, Cutolo M, Smith V, Herrick AL, EULAR Study Group on Microcirculation in Rheumatic Diseases (2017)
An international SUrvey on non‑iNvaSive tecHniques to assess the mIcrocirculation in patients with RayNaud’s phEnomenon (SUNSHINE survey).
Rheumatology International 37:1879-1890.
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Hinze CH, Holzinger D, Lainka E, Haas JP, Speth F, Kallinich T, Minden K, Rieber N, Hufnagel M, Jansson A, Hedrich C, Winowski H, Horneff G, Foell D für die PRO-KIND SJIA-Projektgruppe (2017)
Harmonization of diagnostics and therapy of systemic-onset juvenile idiopathic arthritis in Germany: Process description and key messages. [Harmonisierung der Diagnostik und Therapie der systemischen juvenilen idiopathischen Arthritis in Deutschland: Prozessbeschreibung und Kernaussagen].
Arthritis + Rheuma 37:250-259. German.
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Poppert S, Heideking M, Agostini HJ, Fritzenwanker M, Wüppenhorst N, Muntau B, Henneke P, Kern WV, Krücken J, Junker B, Hufnagel M (2017)
Diffuse unilateral subacute neuroretinitis caused by Ancylostoma.
Emerging Infectious Diseases. 23;343-344.
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Albiński M, Hufnagel M, Schelling J, Fleck T, Siepe M, Zieger B, Stiller B (2016)
Cardiac thrombus with risk of fulminant pulmonary embolism in pediatric antiphospholipid syndrome.
Klinische Pädiatrie. 228:219-222.
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Klotsche J, Raab A, Niewerth M, Sengler C, Ganser G, Kallinich T, Niehues T, Hufnagel M, Thon A, Hospach T, Horneff G, Minden K (2016)
Outcome and trends in treatment of newly diagnosed patients with systemic juvenile idiopathic Arthritis in the National Pediatric Rheumatological Database from 2000 to 2013.
Arthritis & Rheumatology. 2016;68:3023-3034.
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Bielicki JA, Sharland M, Johnson AP, Henderson KL, Cromwell DA; Antibiotic Resistance and Prescribing in European Children project (2016)
(* Dr. Markus Hufnagel is a contributing member of the ARPEC (Antibiotic Prescribing and Resistance in European Children) Project.)
Selecting appropriate empirical antibiotic regimens for paediatric bloodstream infections: application of a Bayesian decision model to local and pooled antimicrobial resistance surveillance data.
Journal of Antimicrobial Chemotherapy. 71:794-802.
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Hufnagel M, König S, Theilacker C (2016)
Importance of local epidemiology in prevalence and resistance of cystic fibrosis-related pathogens.
Pediatric Infectious Diseases Journal. 35:229.
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Jakob A, Whelan J, Kordecki M, Berner R, Stiller B, Arnold R, von Kries R, Roubinis N, Robert M, Grohman J, Höhn R, Hufnagel M (2016)
Kawasaki disease in Germany: A prospective, population-based study adjusted for underreporting.
Pediatric Infectious Diseases Journal. 35:129-134.
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Grom AA, Ilowite NT, Pascual V, Brunner HI, Martini A, Lovell D, Ruperto N; Paediatric Rheumatology International Trials Organisation and the Pediatric Rheumatology Collaborative Study Group*, Leon K, Lheritier K, Abrams K (2016)
(* Dr. Markus Hufnagel is a contributing member of the Paediatric Rheumatology International Trials Organisation.)
Rate and Clinical Presentation of Macrophage Activation Syndrome in Patients With Systemic Juvenile Idiopathic Arthritis Treated With Canakinumab.
Arthritis and Rheumatology. 68:218-28.
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Spyridis N, Syridou G, Goossens H, Versporten A, Kopsidas J, Kourlaba G, Bielicki J, Drapier N, Zaoutis T, Tsolia M, Sharland M, ARPEC Project Group* (2016)
(* Dr. Markus Hufnagel is a contributing member of the ARPEC (Antibiotic Prescribing and Resistance in European Children) Project.)
Variation in paediatric hospital antibiotic guidelines in Europe.
Archives of Disease in Childhood. 101:72-6.
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Rosini R, Campisi E, De Chiara M, Tettelin H, Rinaudo D, Toniolo C, Metruccio M, Guidotti S, Skov Sørensen UB, Kilian M, Ramirez M, DEVANI Consortium*, Janulczyk R, Donati C, Grandi G, Margarit I (2015)
(* Dr. Markus Hufnagel is a contributing member of the DEVANI (Design of a Vaccine Against Neonatal Infections) Study Group.)
Genomic analysis reveals the molecular basis for capsule loss in the group B Streptococcus population.
PLoS ONE. 10:e0125985.
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Bielicki JA, Lundin R, Sharland M, for the ARPEC Project* (2015)
(* Dr. Markus Hufnagel is a contributing member of the ARPEC (Antibiotic Prescribing and Resistance in European Children) Project.)
Antibiotic resistance prevalence in routine bloodstream isolates from children’s hospitals varies substantially from adult surveillance data in Europe.
Pediatric Infectious Diseases Journal. 34:734-41.
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Lestner JM, Versporten A, Doerholt K, Warris A, Roilides E, Sharland M, Bielicki J, Goossens H, ARPEC Project Group* (2015)
(* Dr. Markus Hufnagel is a contributing member of the ARPEC (Antibiotic Prescribing and Resistance in European Children) Project.)
Systematic antifungal prescribing in neonates and children: Outcomes from the Antibiotic Resistance and Prescribing in European Children (ARPEC) study.
Antimicrobial Agents and Chemotherapy. 59:782-789.
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Kunze M, Zumstein K, Markfeld-Erol F, Elling R, Lander F, Prömpeler H, Berner R, Hufnagel M (2015)
Comparison of pre- and intrapartum screening of group B streptococci and adherence to screening guidelines: A cohort study.
European Journal of Pediatrics. 174:827–835.
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Lenz D, Held J, Goerke S, Wagner D, Tintelnot K, Henneke P, Hufnagel M (2015)
Primary cutaneous cryptococcosis in an eight-year-old immunocompetent child: how to treat?
Klinische Pädiatrie. 227:41-44. German.
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de Jong MD, Reusken C, Horby P, Koopmans M, Bonten M, Chiche JD, Giaquinto C, Welte T, Leus F, Schotsman J, Goossens H, on behalf of the PREPARE consortium and affiliated clinical networks* (2014)
(* Dr. Markus Hufnagel is a contributing member of the PREPARE Consortium.)
Preparedness for admission of patients with suspected Ebola virus disease in European hospitals: a survey, August-September 2014.
EuroSurveillance 19(48):pii=20980.
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Da Cunha V, Davies MR, Douarre PE, Rosinski-Chupin I, Margarit I, Spinali S, Perkins T, Lechat P, Dmytruk N, Sauvage E, Ma L, Romi B, Tichit M, Lopez-Sanchez MJ, Descorps-Declere S, Souche E, Buchrieser C, Trieu-Cuot P, Moszer I, Clermont D, Maione D, Bouchier C, McMillan DJ, Parkhill J, Telford JL, Dougan G, Walker MJ; DEVANI Consortium*, Holden MT, Poyart C, Glaser P (2014)
(* Dr. Markus Hufnagel is a contributing member of the DEVANI (Design of a Vaccine Against Neonatal Infections) Study Group.)
Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline.
Nature Communications. 5:4544.
icon Abstract

D’Urzo N, Martinelli M, Pezzicoli A, De Cesare V, Pinto V, Margarit I, Telford JL, Maione D; Members of the DEVANI Study Group* (2014)
(* Dr. Markus Hufnagel is a contributing member of the DEVANI (Design of a Vaccine Against Neonatal Infections) Study Group.)
Acidic pH strongly enhances in vitro biofilm formation by a subset of hypervirulent ST-17 Streptococcus agalactiae strains.
Applied and Environmental Microbiology. 80:2176-2185.
icon Abstract

Hufnagel M, Sixel K, Hammer F, Kropec A, Sava IG, Theilacker C, Berner R, Huebner J (2014)
Detection of opsonic antibodies against Enterococcus faecalis cell wall carbohydrates in immune globulin preparations.
Infection. 42:749-755.
icon Abstract

Puzik A, Geiger J, Hufnagel M (2014)
A young girl with familial Mediterranean fever and abdominal pain.
Clinical Pediatrics. 53:1106-1108.
icon Abstract

Elling R, Hufnagel M, Imm A, de Zoysa A, Lander F, Zumstein K, Kunze M, Lausch E, Krueger M, Henneke P (2014)
Synchronous recurrence of group B streptococcal late-onset sepsis in twins.
Pediatrics. 133:e1388-e1391.
icon Abstract

Blessing K, Toepfner N, Kinzer S, Möllmann C, Geiger J, Serr A, Hufnagel M, Müller C, Krüger M, Ridder GJ, Berner R. (2013)
Lemierre syndrome associated with 12th cranial nerve palsy: A case report and review.
International Journal of Pediatric Otorhinolaryngology. 77:1585-1588.
icon Abstract

Heideking M, Lander F, Hufnagel M, Pfeifer Y, Wicker E, Krause G, Berner R (2013)
Antibiotic susceptibility profiles of neonatal invasive isolates of Escherichia coli from a 2-year nationwide surveillance study in Germany, 2009–2010
European Journal of Clinical Microbiology and Infectious Diseases. 32:1221–1223.

icon Abstract

Simon A, Müller A, Kaiser P, Töpfner N, Berner R, Laws H-J, Knorr M, Hufnagel M, Beyersdorff A, Heister P, Becker C, Liese JG, Tenenbaum T (2013)
The Paed IC project: Antibiotic stewardship and hospital hygiene to prevent infection with resistant pathogens. [Das Paed IC Projekt: Antibiotic Stewardship und Infektionsprävention zur Vermeidung von nosokomialen Infektionen durch resistente Infektionserreger.]
Klinische Pädiatrie 225; 93-95. German.
icon Citation

Yao K, Poulsen K, Maione D, Rinaudo CD, Baldassarri L, Telford JL, Sørensen UBS, members of the DEVANI Study Group*, Kilian M (2013)
(* Dr. Markus Hufnagel is a contributing member of the DEVANI (Design of a Vaccine Against Neonatal Infections) Study Group.)
Capsular Gene Typing of Streptococcus agalactiae Compared to Serotyping by Latex Agglutination
Journal of Clinical Microbiology. 51(2):503-7.
icon Abstract

Toepfner N, Henneke P, Berner R, Hufnagel M (2012)
Impact of technical training on rapid antigen detection tests (RADT) in group A streptococcal tonsillopharyngitis
European Journal of Clinical Microbiology and Infectious Diseases, 32:609-611.
icon Abstract

Meinicke H, Heinzmann A, Geiger J, Berner R, Hufnagel M (2012)
Symptoms of Shrinking Lung Syndrome Reveal Systemic Lupus Erythematosus in a 12-Year-Old Girl
Pediatric Pulmonology, 48:1246–1249.
icon Abstract

Hufnagel M, Henneke P, Schmitt-Graeff A (2012)
IgG4-Related Disease
New England Journal of Medicine. 366:1643-44, Author reply 1646-7.
icon Abstract

Jakob A, Creutzfeldt R, Staszewski O, Winterpacht A, Berner R, Hufnagel M (2012)
Primary erythromalalgia in a 12-year-old boy: Positive response to sodium channel blockers despite negative SCN9A mutations.
Klinische Pädiatrie. 224:309–312.
icon Abstract

Farmand S, Henneke P, Hufnagel M, Berner R (2012)
Significant decline in the erythromycin resistance of group A streptococcus isolates at a German paediatric tertiary care centre.
European Journal of Clinical Microbiology and Infectious Diseases. 31:707-710.
icon Abstract

Jessen B, Maul-Pavicic A, Ufheil H, Vraetz T, Enders A, Lehmberg K, Längler A, Gross-Wieltsch U, Bay A, Kaya Z, Bryceson YT, Koscielniak E, Badawy S, Davies G, Hufnagel M, Schmitt-Gräff A, Aichele P, zur Stadt U, Schwarz K, Ehl S (2011)
Subtle differences in CTL cytotoxicity determine susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome.
Blood, 118:4620-4629.
icon Abstract

Fluegge K, Wons J, Spellerberg B, Swoboda S, Siedler A, Hufnagel M, Berner R (2011)
Genetic Differences Between Invasive and Noninvasive Neonatal Group B Streptococcal Isolate.
Pediatric Infectious Disease Journal. 30:1027-1031
icon Abstract

Afshar B, Broughton K, Creti R, Detcheva A, Hufnagel M, Kriz P, Lambertsen L, Lovgren M, Melin P, Orefici G, Poyart C, Radtke A, Rodriguez-Granger J, Skov Sørensen UB, Telford J, Valinsky L, Zachariadou L, Members of the DEVANI study group*, Efstratiou A. (2011)
(* Dr. Markus Hufnagel is a contributing member of the DEVANI (Design of a Vaccine Against Neonatal Infections) Study Group.)
International External Quality Assurance for Laboratory Diagnosis and Typing of Streptococcus agalactiae (group B streptococci).
Journal of Clinical Microbiology. 49:1475-1482
icon Abstract

Maul-Pavicic A, Chiang S, Rensing-Ehl A, Fauriat C, Hufnagel M, Schulze I, Bass T, Schamel W, Schwarz K, Bryceson Y, Ehl S (2011)
Orai1 is required for target cell-induced NK cell degranulation and cytokine production.
Proceedings of the National Academy of Science. 108:3324-3329
icon Abstract

Schenk T, Maier B, Hufnagel M, Strahm B, Kontny U, Neumann-Haefelin D, Falcone V (2011)
Persistence of human bocavirus DNA in immunocompromised children.
Pediatric Infectious Diseases Journal, 30:82-84
icon Abstract

Hatz C, Inoubli S, Loutan L, Genton B, Behrens R, Hufnagel M (2010)
Japanese encephalitis: Risk for endemic populations and for travellers. [Encéphalite japonaise: risque pour les populations vivant en zones d'endémie et pour les voyageurs.]
Revue Médicale Suisse, 6(248):956-9. French.
icon Abstract

Carlsson G, Hufnagel M, Jansen O, Claviez A, Nabavi A (2010)
Rapid recovery of motor and cognitive functions after resection of a right frontal lobe meningioma in a child.
Child's Nervous System, 26:105-111
icon Abstract

Hatz C, Werlein J, Mutsch M, Hufnagel M, Behrens RH (2009)
Japanese Encephalitis: Defining Risk Incidence for Travelers to Endemic Countries and Vaccine Prescribing From the UK and Switzerland.
Journal of Travel Medicine, 16:200-203
icon Abstract

von Schnakenburg C, Hufnagel M, Superti-Furga A, Rieger-Fackeldey E, Berner R (2009)
Successful Continuous Renal Replacement Therapy in a Neonate with Early-onset Group B Streptococcal Sepsis and Multi-organ Dysfunction Syndrome. [Multiorganversagen bei Early-onset-B-Streptokokkensepsis: Erfolgreicher Einsatz einer kontinuierlichen venovenösen Hämofiltration (CVVH) beim Neugeborenen.]
Klinische Pädiatrie, 221:251-3. German.
icon Abstract

Hufnagel M, Burger A, Bartelt S, Henneke P, Berner R (2008)
Secular trends in pediatric bloodstream infections over a 20-year period at a tertiary care hospital in Germany.
European Journal of Pediatrics, 167:1149-59
icon Abstract

Hufnagel M, Liese C, Löscher C, Kunze K, Prömpeler H, Berner R, Krüger M (2007)
Enterococcal colonization of infants in a neonatal intensive care unit: Seasonal patterns and associated risk factors.
BMC Infectious Diseases, 7:107
icon Abstract

Schenk T, Strahm B, Kontny U, Hufnagel M, Neumann-Haefelin D, Falcone V (2007)
Disseminated human bocavirus infection in a child following hematopoietic stem cell transplantation.
Emerging Infectious Diseases, 13:1425-1427
icon Abstract

Hufnagel M, Carey VJ, Baldassarri L, Reinert RR, Huebner J (2006)
Distribution of four capsular serotypes of Enterococcus faecalis among clinical isolates from different geographical origins and infection sites.
Infection, 34:22-25
icon Abstract

Buck D, Malivert L, de Chasseval R, Barraud A, Fondanèche M-C, Sanal O, Plebani A, Stèphan J-L, Hufnagel M, le Deist F, Fischer A, Durandy A, de Villartay JP, Revy P (2006)
Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly.
Cell, 124:287-299
icon Abstract

Hufnagel M, Czech N, Schmidt M, Hero B, Claviez A (2006)
Neuroblastoma Stage 4S with 123I-MIBG-positive bone marrow involvement.
Pediatric Blood & Cancer, 46:264-265
icon Citation

Hufnagel M, Huebner J (2005)
Analysis of the specific immune response against capsular polysaccharides of two patients with systemic enterococcal infections.
Infection, 33:373-376
icon Abstract

Kropec A, Hufnagel M, Zimmermann K, Huebner J (2005)
In vitro assessment of the host response against Enterococcus faecalis in probiotic preparations.
Infection, 33:377-379
icon Abstract

Hufnagel M, Kropec A, Theilacker C, Huebner J (2005)
Naturally acquired antibodies against four Enterococcus faecalis capsular polysaccharides in normal human sera.
Clinical and Vaccine Immunology (formerly Clinical and Diagnostic Laboratory Immunology), 12:930-934
icon Abstract

Hufnagel M, Hancock LE, Koch S, Theilacker C, Gilmore MS, Huebner J (2004)
Serological and genetic diversity of capsular polysaccharides in Enterococcus faecalis.
Journal of Clinical Microbiology, 42:2548-2557
icon Abstract

Hufnagel M, Koch S, Creti R, Baldassarri L, Huebner J (2004)
A putative sugar-binding transcriptional regulator in a novel gene locus in Enterococcus faecalis contributes to biofilm formation and prolonged bacteremia in mice.
Journal of Infectious Diseases, 189:420-430
icon Abstract

Hufnagel M, Koch S, Kropec A, Huebner J (2003)
Opsonophagocytic assay as a potentially useful tool for assessing safety of Enterococcal preparation.
International Journal of Food Microbiology, 88:263-267
icon Abstract

Lässker U, Harder TC, Hufnagel M, Suttorp M (2002)
Rapid molecular discrimination of infection with wild-type varicella zoster virus or varicella vaccine virus.
Infection, 30:320-322
icon Abstract

Harder TC, Hufnagel M, Zahn K, Beutel K, Schmitt HJ, Ullmann U, Rautenberg P (2001)
A new LightCycler™ polymerase chain reaction for rapid and sensitive quantification of parvovirus B19 DNA guides therapeutic decision-making in chronic infections.
Journal of Clinical Microbiology, 39:4413-4419
icon Abstract

Eichmann D, Hufnagel M, Quick P, Santer R (1999)
Treatment of hyperinsulinemic hypoglycemia with nifedipine.
European Journal of Pediatrics, 158:204-206
icon Abstract

Muller D, Hufnagel M, Suttorp (1999)
Accidental overdose of vancomycin in preterm twins.
Pediatric Infectious Diseases Journal, 18:744-745
icon Citation

Hufnagel M, Eichmann D, Stieh J, Santer R (1998)
Further evidence for a dominant form of familial persistent hyperinsulinemic hypoglycemia of infancy: a family with documented hyperinsulinemia in two generations.
Journal of Clinical Endocrinology and Metabolism, 83:2215-2216
icon Citation

Dai WJ, Bartens W, Kohler G, Hufnagel M, Kopf M, Brombacher F (1997)
Impaired macrophage listericidal and cytokine activities are responsible for the rapid death of Listeria monocytogenes-infected IFN-gamma receptor-deficient mice.
Journal of Immunology, 158:5297-5304.
icon Abstract

Hufnagel M, Niemeyer C, Zimmerhackl LB, Tuchelmann T, Sauter S, Brandis M (1995)
Hemophagocytosis: a complication of acute Q fever in a child.
Clinical Infectious Diseases, 21:1029-1031.
icon Abstract

Hufnagel M, Tuchelmann, Zimmerhackl LB, Leititis JU, Tüchelmann T, Brandis M, Brem S, Schindera F (1994)
Acute renal failure without liver involvement in Leptospirosis icterohaemorrhagiae infection. [Akutes Nierenversagen ohne Leberbeteiligung bei Leptospira icterohaemorrhagiae-Infektion.]
Monatsschrift Kinderheilkunde 142:957-960. German.

icon Citation


Medical Reviews

 

Spielberger B, Pfeil J, Assaad K, von Both U, Janda A, Kitz C, Kobbe R, Kunze M, Lindert J, Ritz N, Trapp S, Hufnagel M (2022).
Infectious diseases-related health care based upon the example of Ukrainian refugees.
[Infektiologische Versorgung minderjähriger Flüchtlinge am Beispiel der Ukraine]

Monatschrift Kinderheilkunde, 170:1103-12 (published online 23 Sept 2022). DOI: 10.1007/s00112-022-01607-4. German.
icon Abstract

Töpfner N, Alberer M, Ankermann T, Bender S, Berner R, de Laffolie J, Dingemann J, Heinicke D, Haas J-P, Hufnagel M, Hummel T, Huppertz H-I, Knuf M, Kobbe R, Lücke T, Riedel J, Rosenecker J, Wölfle J; Schneider B, Schneider D, Schriever V, Schroeder A, Stojanov S, Tenenbaum T, Trapp S, Vilser D, Brinkmann F, Behrends U (2022).
Recommendation for standardized medical care for children and adolescents with long COVID.
[Einheitliche Basisversorgung von Kindern und Jugendlichen mit Long COVID. Stellungnahme einer multidisziplinären Arbeitsgruppe der DGKJ-Konvent-Gesellschaften (Stand: Februar 2022).]

Monatschrift Kinderheilkunde, 170:539-547, (published 25 May 2022). DOI: 10.1007/s00112-021-01408-1. German.
icon Abstract

Brinkmann F, Feiterna-Sperling C, Günther A, Breuer C, Hartmann P, Hufnagel M, Priwitzer M, Otto-Knapp R, Witte P, Diel R, Häcker B (2022).
Screening for tuberculosis among refugee children and adolescents from Ukraine. A recommendation of the German Central Committee against Tuberculosis e.V. (DZK), together with the writing group pediatric tuberculosis of the Society of Pediatric Pneumology (GPP).
[Untersuchung auf Tuberkulose bei geflüchteten Kindern und Jugendlichen aus der Ukraine. Eine Handlungsempfehlung des Deutschen Zentralkomitees zur Bekämpfung der Tuberkulose e.V. (DZK) in Zusammenarbeitmit der Arbeitsgruppe Leitlinie Tuberkulose im Kindes- und Jugendalter und der Gesellschaft für pädiatrische Pneumologie (GPP).]

Pneumologie, 24 May 2022. DOI: 10.1055/a-1832-2546. German.
icon Abstract

Pfeil J, Assaad K, von Both U, Janda A, Kitz C, Kobbe R, Kunze M, Lindert J, Ritz N, Trapp S, Hufnagel M (2022).
Updated recommendations on the treatment of infectious diseases in refugees in childhood and adolescence in Germany (situation as of 30 March 2022), registered as S1 guidelines (AWMF-Register Nr. 048-017). Statement of the German Society for Pediatric Infectious Diseases (DGPI e.V.), the Society for Tropical Pediatrics and International Child Health (GTP e.V.), the Professional Association of Doctors in Pediatric and Adolescent Medicine (BVKJ e.V.), and the German Society for Pediatric and Adolescent Medicine (DGKJ e.V.).
[Aktualisierte Empfehlungen zur infektiologischen Versorgung von Flüchtlingen im Kindes- und Jugendalter in Deutschland (Stand 30. März 2022). Angemeldet als S1-Leitlinie (AWMV Register Nr. 048-017). Stellungnahme der Deutschen Gesellschaft für Pädiatrische Infektiologie (DGPI e.V.), der Gesellschaft für Tropenpädiatrie und Internationale Kindergesundheit (GTP e.V.), des Berufsverbandes der Kinder-und Jugendärzte (BVKJ e.V.) und der Deutschen Gesellschaft für Kinder- und Jugendmedizin (DGKJ e.V.).]

Monatschrift Kinderheilkunde, 25 May 2022; 1-15. DOI: 10.1007/s00112-022-01499-4. German.
icon Abstract

Freudenhammer M, Hufnagel M (2021).
Travelling with children and adolescents with rheumatic diseases.
[Reisen bei Kindern und Jugendlichen mit rheumatischen Erkrankungen.]

Zeitschrift für Rheumatologie 80, 620-628 (2021). DOI: 10.1007/s00393-021-01002-6. German.
icon Abstract

Hufnagel M, Simon A, Trapp S, Liese J, Reinke S, Klein W, Parlowsky T, Pfeil J, Renk H, Berner R, Hübner J, Kummer S, Tillmann R (2020).
Standard antibiotic treatment of frequent infectious diseases in outpatient pediatrics. Recommendations of the working group on antibiotic stewardship in outpatient pediatrics (ABSaP) of the German Society for Pediatric Infectious Diseases (DGPI), the Professional Association of Pediatric and Adolescent Physicians (BVKJ) and the Bielefeld Initiative AnTiB.
[Antibiotische Standardtherapie häufiger Infektionskrank-heiten in der ambulanten Pädiatrie – Empfehlungen der Arbeitsgemeinschaft Antibiotic Stewardship ambulante Pädiatrie (ABSaP) der Deutschen Gesellschaft für Pädiatrische Infektiologie (DGPI), des Berufsverbandes der Kinder- und Jugendärzte (BVKJ) und der Bielefelder Initiative AnTiB.]

Monatschrift Kinderheilkunde, (published online 17 Sept 2020). German.
icon Abstract

Simon A, Hübner J, Knuf M, Hufnagel M, Berner R (2020).
Management of care for neonates born to SARS-CoV-2 positive women with or without clinical symptoms (COVID-19)
Klinische Pädiatrie, 232:173-177
icon Abstract

Korinthenberg R, Trollmann R, Felderhoff-Müser U, Bernert G, Hackenberg A, Hufnagel M, Pohl M, Hahn G, Mentzel HJ, Sommer C, Lambeck J, Mecher F, Hessenauer M, Winterholler C, Kempf U, Jacobs BC, Rostasy K, Müller-Felber W (2020).
Diagnosis and treatment of Guillain-Barré Syndrome in childhood and adolescence: An evidence- and consensus-based guideline
European Journal of Pediatric Neurology, 25:5-16.
icon Abstract

Hübner J, von Both U, Tenenbaum T, Weichert S, Liese J, Hufnagel M, Pecar A, Strenger V, Simon A (2019).
Antibiotic stewardship – Conception and implementation in the inpatient pediatric medicine: A new AWMF S2k guideline (AWMF registration number 048/15) coordinated by the German Society for Pediatric Infectious Diseases. [Antibiotic Stewardship – Konzeption und Umsetzung in der stationären Kinder- und Jugendmedizin: Eine neue AWMF S2k Leitlinie (AWMF-Registernummer 048/15) unter Federführung der Deutschen Gesellschaft für Pädiatrische Infektiologie.]
Monatsschrift Kinderheilkunde 167:631-6. German.
icon Abstract

Korinthenberg R, Felderhoff U, Bernert G, Hackenberg A, Hufnagel M, Hahn G, Winterholler C, Pohl M, Rostasy K, Müller-Felber W, Kempf U, Meerpohl J, Mentzel HJ, Hessenauer M. Lambeck J, Jacobs BC, Sommer C (2019)
Diagnosis and treatment of Guillain-Barré Syndrome in children and adolescents. [Diagnose und Therapie des Guillain-Barré Syndroms im Kindes- und Jugendalter.]
S3 Leitlinie (AWMF-Registernummer 022/008). German.
icon Citation

Pfeil J, Hufnagel M (2018)
Rational diagnostics and therapies in child refugees.
Pediatric Infectious Disease Journal. 37:272-4.
icon Citation

Simon A, von Both U, Hufnagel M, Hübner J (2018)
Antibiotic stewardship in pediatric and adolescent medicine.
[Antibiotic Stewardship in der Kinder- und Jugendmedizin]
.

Monatsschrift Kinderheilkunde 166;48-56. German.
icon Citation

Simon A, von Both U, Hufnagel M, Hübner J (2018)
Antibiotic stewardship in pediatric and adolescent medicine.
[Antibiotic Stewardship in der Kinder- und Jugendmedizin.]

Deutsches Arzteblatt (On press). German.
icon Citation

Hufnagel M (2017)
Readmission after pertussis infections (real-life questions and answers).
[Wiederzulassung nach/bei Pertussis-Infektion (Fragen & Antworten aus der Praxis).]

Pädiatrische Praxis 87:553-4. German.
icon Citation

Simon A, Tenenbaum T, Huppertz HI, Trapp S, Prelog M, Hufnagel M, Knuf M, Rose MA, Forster J, Nicolai T, Berger C, Nadal D, Hübner J, Berner R, Liese J (2017)
Diagnosis and therapy of respiratory tract infections (without community-acquired pneumonia) in pediatric outpatients without severe underlying diseases.
[Diagnose und Therapie von Atemwegsinfektionen (ohne ambulant erworbene Pneumonie) bei ambulant behandelten Kindern ohne schwerwiegende Grunderkrankung.]

Monatsschrift Kinderheilkunde 165:711–724. German.
icon Citation

Jakob A, Hufnagel M (2017)
Steroid therapy and Kawasaki disease: Validity of current studies (Reader Forum).
[Steroidtherapie und Kawasaki-Syndrom: Aussagekraft vorliegender Studien (Leserforum).]

Monatsschrift Kinderheilkunde 165:184-5. German.
icon Citation

Simon A, Tenenbaum T, Huppertz HI, Trapp S, Prelog M, Hufnagel M, Knuf M, Rose MA, Forster J, Nicolai T, Berger C, Nadal D, Hubner J, Berner R, Liese J (2016)
Respiratory tract infections in children: When are antibiotics indicated — and when not.
[Atemwegsinfektionen bei Kindern: Wann Antibiotika indiziert sind – und wann nicht.]

Deutsches Ärzteblatt 113(21):[14]; DOI: 10.3238/PersInfek.2016.05.27.04. German.
icon Citation

Kobbe R, Kitz C, Trapp S, Pfeil J, Hufnagel M (2016)
Care of child refugees: Emphasis on diagnostics and prevention of infectious diseases.
[Versorgung von minderjährigen Flüchtlingen: Schwerpunkt Diagnostik und Prävention von Infektionskrankheiten.]

Notfall + Rettungsmedizin. 19:346-54. German.
icon Citation

Hufnagel M (2016)
Second vaccinations against measles, mumps and rubella after the 15th month of life: Real-life questions and answers. [Zweitimpfung gegen Masern, Mumps, Röteln ab dem 15. Lebensmonat: Fragen & Antworten aus der Praxis.]
Pädiatrische Praxis. 86:183-5. German.
icon Citation

von Both U, Simon A, Hufnagel M, Hübner J (2016)
Antibiotic Stewardship in der Pädiatrie. [Antibiotic Stewardship in Pediatrics].
Kinder- und Jugendarzt. 47:212-20. German.
icon Citation

Pfeil J, Kobbe R, Trapp S, Kitz C, Hufnagel M (2016)
Empfehlungen zur infektiologischen Versorgung von Flüchtlingen im Kindes- und Jugendalter in Deutschland: Stellungnahme der Deutschen Gesellschaft für Pädiatrische Infektiologie, der Gesellschaft für Tropenpädiatrie und Internationale Kindergesundheit und des Berufsverbandes der Kinder- und Jugendärzte.
[Recommendations for the diagnosis and prevention of infectious diseases in pediatric and adolescent refugees in Germany: Statement of the German Society of Pediatric Infectious Diseases, the Society of Tropical Pediatrics and International Child Health, and the Professional Association of Pediatricians].

Internist 57:416-33. German.
icon Abstract

Simon A, Agyeman P, Amman R, Attarbashi A, Behrends U, Berger C, Groll AH, Hamprecht A, Hufnagel M, Laws HJ, Lehrnbecher T (2016)
AWMF S2k guideline of the Germany Society for Pediatric Infectious Diseases (DGPI) and the Society of Pediatric Oncology and Hematology (GPOH).
[AWMF S2k Leitlinie der Deutschen Gesellschaft für pädiatrische Infektiologie (DGPI) und Gesellschaft Pädiatrische Onkologie und Hämatologie (GPOH)].
Diagnostics and therapy in children with oncological underlying diseases, fever and granulocytopenia (febrile neutropenia), excluding children with allogenic stem cell transplantation.
[Diagnostik und Therapie bei Kindern mit onkologischer Grunderkrankung, Fieber und Granulozytopenie (mit febriler Neutropenie) außerhalb der allogenen Stammzelltransplantation.]

AWMF registration number 048/14, Version 23 Jan. 2016. German.
icon Citation

Bosk A, Groll A, Hufnagel M, Lehrnbecher T, Pöschl J, Simon A, Wendt C (2015)
AWMF S2k guidelines of the Germany Society for Pediatric Infectious Diseases (DGPI) and other German medical societies.
[AWMF S2k Leitlinie der Deutschen Gesellschaft für pädiatrische Infektiologie (DGPI) und anderer deutscher medizinischer Gesellschaften].
Sepsis in children beyond the neonatal period. [Sepsis bei Kindern jenseits der Neonatalperiode.]
AWMF registration number 024/25, Version December 2015. German.
icon Citation

Pfeil J, Kobbe R, Trapp S, Kitz C, Hufnagel M (2016)
Versorgung von Flüchtlingen: Diagnostik und Prävention im Kindes- und Jugendalter.
[Medical care of refugees: Diagnostics and prevention in children and adolescents].

Deutsches Ärzteblatt. 113:A134-6. German.
icon Abstract

Pfeil J, Kobbe R, Trapp S, Kitz C, Hufnagel M (2015)
Empfehlungen zur infektiologischen Versorgung von Flüchtlingen im Kindes- und Jugendalter in Deutschland. Stellungnahme der Deutschen Gesellschaft für Pädiatrische Infektiologie, der Gesellschaft für Tropenpädiatrie und Internationale Kindergesundheit und des Berufsverbandes der Kinder- und Jugendärzte.
[Recommendations for the diagnosis and prevention of infectious diseases in pediatric and adolescent refugees in Germany. Statement of the German Society of Pediatric Infectious Diseases, the Society of Tropical Pediatrics and International Child Health, and the Professional Association of Pediatricians].

Monatsschrift Kinderheilkunde. 163:1269–1286. German.
icon Abstract

Ritz N, Hufnagel M, Gérardin P (2015).
Chikungunya in children.
Pediatric Infectious Diseases Journal. 34:789-91.
icon Abstract

Strothmann JML, Henneke P, Hufnagel M (2013)
IgG4-related disease (IgG4-RD) – also a childhood disease. [IgG4-related disease (IgG4-RD) – auch eine Erkrankung des Kindesalters.]
Arthritis + Rheuma. 33:317-322. German.
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Elling R, Henneke P, Hatz C, Hufnagel M (2013)
Dengue fever in children: Where are we now?
Pediatric Infectious Disease Journal. 32:1020-1022.
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Bode SFN, Hufnagel M, Speckmann C (2012)
Vaccination under immunosuppression and in immunocompromised patients. [Impfungen bei Immunsuppression und bei immunkompromittierten Patienten.]
Pädiatrische Praxis. 79:647-657. German.
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Elling R, Kontny U, Henneke P, Hufnagel M (2012)
Clinical evaluation of peripheral lymph node swelling in children. [Abklärung peripherer Lymphknotenvergrößerungen im Kindesalter.]
Monatsschrift Kinderheilkunde. 160:901-918. German.
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Elling R, Hufnagel M, Henneke P (2012)
Skin bleeding associated with infection. [Infektionsassoziierte Hautblutungen.]
Monatsschrift Kinderheilkunde. 160:545–555. German.
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Rodriguez-Granger J, Alvargonzalez JC, Berardi A, Berner R, Kunze M, Hufnagel M, Melin P, Decheva A, Orefici G, Poyart C, Telford J, Efstratiou A, Killian K, Krizova P, Baldassarri L, Spellerberg S, Puertas A and Rosa-Fraile M. (2012)
Prevention of group B streptococcal neonatal disease revisited: The DEVANI European Project.
European Journal of Clinical Microbiolology and Infectious Diseases. 31:20972104.
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Kenzel S, Hufnagel M, Berner R, Henneke P (2010)
Pneumococcus Vaccination and Serotype Replacement: Do we need a new vaccine or vaccination concept? [Pneumokokkenimpfung und Serotyp-Replacement: Brauchen wir ein neues Impf(stoff)konzept?.]
Deutsche Medizinische Wochenschrift 135:1198-1200. German.
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Lander F, Hufnagel M, Berner R (2010)
Antimicrobial therapy for sepsis in pediatrics. [Antimikrobielle Therapie der Sepsis in der Pädiatrie.]
Pädiatrische Praxis 75:233-245. German.
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Weih M, Schaller G, Degirmenci U, Hufnagel M, Kornhuber J (2009)
Differential diagnosis of neurodegenerative disorders in young adults. [Differentialdiagnosen zu neurodegenerativen Erkrankungen im jungen Erwachsenenalter.]
Fortschritte der Neurologie-Psychiatrie 77(11):662-668. German.
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Hufnagel M, Berner R (2009)
Lymphadenitis colli – a guideline for diagnostic and therapeutic procedures. [Lymphadenitis colli – ein Leitfaden für das diagnostische und therapeutische Vorgehen.]
Kinder- und Jugendarzt. 40:300-11. German.
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Hufnagel M, Henneke P, Krüger M, Berner R (2008)
Severe, rapid-onset sepsis in childhood. [Die foudroyante Sepsis im Kindesalter.]
Up2date Notfallmedizin, 3:149-171. German.

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Hufnagel M, Burger A, Zwigart M, Berner R (2008)
Epidemiology of Staphylococcus aureus bacteremia in childhood – "secular trends". [Epidemiologie von Staphylococcus aureus-Bakteriämien im Kindesalter – "säkulare Trends."]
Kinder- und Jugendmedizin, 8:88-92. German.
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Hufnagel M, Berner R (2007)
Lice, fleas and other beasts. [Läuse, Flöhe und anderes Getier.]
Kinderkrankenschwester, 26:283-8. German.
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Hufnagel M, Neef V, Berner R (2007)
White tongue in Infants – not always oral thrush. [Die weiße Zunge beim Säugling – nicht immer ein Mundsoor.]
Kinderärztliche Praxis 78:152-154. German.

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Koch S, Hufnagel M, Huebner J (2004)
Treatment and prevention of enterococcal infections – alternative and experimental approaches.
Expert Opinion on Biological Therapy, 4:1519-31
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Koch S, Hufnagel M, Theilacker C, Huebner J (2004)
Enterococcal infections: host response, therapeutic, and prophylactic possibilities.
Vaccine, 22:822–830
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Hufnagel M (2001)
Hand, mouth, foot disease. [Hand-Mund-Fuß-Krankheit.]
Deutsche Medizinische Wochenschrift, 126:1125-1126. German.
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Hufnagel M, Schmitt HJ (1999)
Acute fever in travelers returning from the tropics. [Akutes Fieber bei Tropenrückkehrern.]
Kinderärztliche Praxis 7:496-503. German.
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Hufnagel M, Schmitt HJ (1999)
Chronic fever in travelers returning from the tropics. [Chronisches Fieber bei Tropenrückkehrern.]
Kinderärztliche Praxis 7:504-509. German.

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Medical Textbook Contributions

 

Hufnagel M, Schmitt HJ (2014, 2007, 2003, 2001)
Chlamydia Infections. [Chlamydien-Infektionen.]
Chapter in "Pädiatrie Grundlagen und Praxis, [Pediatric Fundamentals and Practice]," eds. Hoffmann GF, Lentze MJ, Spranger J, Zepp F. Springer-Verlag Berlin, pp. 889-891. German.
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Hufnagel M, Schmitt HJ (2014, 2007, 2003, 2001)
Q-Fever. [Q-Fieber.]
Chapter in "Pädiatrie Grundlagen und Praxis,[Pediatric Fundamentals and Practice]," eds. Hoffmann GF, Lentze MJ, Spranger J, Zepp F. Springer-Verlag Berlin, pp. 895-896. German.
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Hufnagel M, Schmitt HJ (2014, 2007, 2003, 2001)
Sepsis. [Sepsis.]
Chapter in "Pädiatrie Grundlagen und Praxis, [Pediatric Fundamentals and Practice]," eds. Hoffmann GF, Lentze MJ, Spranger J, Zepp F. Springer-Verlag Berlin, pp. 842-848. German.
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Hufnagel M, Schmitt HJ (2014, 2007, 2003, 2001)
Toxic Shock Syndrome. [Toxisches Schocksyndrom.]
Chapter in "Pädiatrie Grundlagen und Praxis, [Pediatric Fundamentals and Practice]," eds. Hoffmann GF, Lentze MJ, Spranger J, Zepp F. Springer-Verlag Berlin, pp. 849-851. German.
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Zepp F, Schmitt HJ, Hufnagel M (2014, 2007, 2003, 2001)
Typhoid and Cholera Vaccination. [Typhus- und Choleraschutzimpfung.]
Chapter in "Pädiatrie Grundlagen und Praxis, [Pediatric Fundamentals and Practice]," eds. Hoffmann GF, Lentze MJ, Spranger J, Zepp F. Springer-Verlag Berlin, pp. 132-133. German.
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Nicolai T, Hübner J, Hufnagel M, Schaad UB, Wirbelauer J (2013)
Sepsis. [Sepsis.]
Chapter in “Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]”, ed. Deutsche Gesellschaft für Pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp 776-784. German.
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Hübner J, Hufnagel M (2013)
Peritonitis [Peritonitis].
Chapter in “Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]”, ed. Deutsche Gesellschaft für Pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp 773-775. German.
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Hübner J, Arweiler N, Hufnagel M (2013)
Odontogenic Infections [Odontogene Infektionen]
Chapter in “Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]”, ed. Deutsche Gesellschaft für Pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp 768-772. German.
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Herting E, Hufnagel M, Kunze M, Spellerberg B, Roos R, Berner R (2013)
Infections by β-hemolytic group B (GBS) streptococci [Infektionen durch β-hämolysierende Streptokokken der Gruppe B (GBS)]
Chapter in “Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]”, ed. Deutsche Gesellschaft für Pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp 517-520. German.
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Bialek R, Bernard H, Hufnagel M (2013)
Q-Fever [Q-Fieber]
Chapter in “Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]”, ed. Deutsche Gesellschaft für Pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp 463-465. German.
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Hufnagel M, Knuf M (2013, 2009, 2003, 2000)
Leptospirosis. [Leptospirose.]
Chapter in "Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]," ed. Deutsche Gesellschaft für pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp. 369-371. German.
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Hufnagel M, Lemmen S, Simon A (2013, 2009, 2003, 2000)
Legionella. [Legionellose.]
Chapter in "Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]," ed. Deutsche Gesellschaft für pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp. 358-360. German.
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Hufnagel M, [H-R Brodt], Panning M, Ritz N (2013)
Viral Hemorrhagic Fevers [Hämorrhagische Fieber durch Viren]
Chapter in “Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]”, ed. Deutsche Gesellschaft für Pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp 275-283. German.
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Hufnagel M, Heininger U, Hübner J (2013)
Enterococcal Infections [Enterokokken-Infektionen]
Chapter in “Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]”, ed. Deutsche Gesellschaft für Pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp 242-253. German.
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Hufnagel M, Panning M (2013)
Dengue Fever [Dengue-Fieber]
Chapter in “Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]”, ed. Deutsche Gesellschaft für Pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp 281-221. German.
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Ritz N, Hufnagel M (2013)
Chikungunya Fever [Chikungunya-Fieber]
Chapter in “Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]”, ed. Deutsche Gesellschaft für Pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp 195-196. German.
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Huppertz HI, Hufnagel M, Niehues T (2013)
Infectious Prophylaxis in Immune-modulating Drug Therapy [Infektionsprophylaxe bei immunmodulatorischer Therapie]
Chapter in “Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]”, ed. Deutsche Gesellschaft für Pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp 129-131. German.
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Hufnagel M (2008)
Pneumococcus: The Clinical Picture. [Pneumokokken: Das Krankheitsbild.]
Chapter in "Konjugatimpfstoffe und Infektionskrankheiten durch bekapselte Erreger." [Conjugate Vaccines and Infectious Diseases Caused by Capsulated Microorganisms],
ed. Berner R. Uni-Med Science, 1:25-35. German.

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Keywords

 

  • Pediatrics, Pediatric Medicine, Infectious Diseases, Infectious Disease Specialist, Pediatric Rheumatology, Rheumatologist, Immunology, Tropical Medicine, Travel Medicine, Vaccinology, vaccines, Freiburg, University Clinic, Research
  • Pädiatrie, pädiatrische Medizin, Kindermedizin, Jugendmedizin, Kinderarzt, Arzt, Infektiologie, Infektiologue, pädiatrische Rheumatologie, Rheumatologue, Immunologie, Tropenmedizin, Reisemedizin, Vakzinologie, Impfungen, Freiburg, Uniklinik, Uniklinikum, Forschung

Contact

 

Dr. Markus Hufnagel
Center for Pediatrics and Adolescent Medicine, Clinic I
Department of Pediatric Infectious Diseases and Rheumatology
University Medical Center Freiburg

Mathildenstr. 1
D-79106 Freiburg
Germany

Tel: +49 (0)761-270-43000
Fax: +49 (0)761-270- 44730
Email:
Website: markushufnagel.com