Prof. Dr. med. Markus Hufnagel, DTM&H

Dr. Markus HufnagelDr. Markus Hufnagel is a specialist in pediatric and adolescent medicine, infectious diseases, pediatric rheumatology, immunology, tropical medicine, travel medicine and vaccinology. As Director of Pediatric Rheumatology and Deputy Director of Pediatric Infectious Diseases at the University Children's Hospital in Freiburg, Germany, Dr. Hufnagel is responsible for patient care and care management, medical teaching and medical research. Additionally, he coordinates the local vaccination program in Freiburg's refugee camp. His current research focuses on antibiotic usage and resistance, infections with gram-positive pathogens, and medical care of refugees. Active in numerous international projects, Dr. Hufnagel regularly collaborates with European and North American partners, as well as with several NGOs working in resource-poor countries.

Professional Experience

Curriculum vitae

 

2010 – Present

  • Professor of Pediatric and Adolescent Medicine (as of 2016)
  • Attending Physician ("Oberarzt")
  • Infectious Diseases Specialist (Board Certified as of 2009)
  • Pediatric Rheumatologist (Board Certified as of 2010)
  • Director of Pediatric Rheumatology and Deputy Director of Pediatric Infectious Diseases (2012 – present)
  • Coordinator of the Refugee Camp Vaccination Program in Freiburg (2015 – present)
  • Director of Pediatric Outpatient Clinic (2010 – 2012)
  • Lecturer in Pediatric Infectious Diseases, Tropical Medicine, Travel Medicine, Vaccinology, Immunology and Rheumatology
    University Children’s Hospital, Freiburg, Germany

2009

2007 – 2008

Apr – May 2007

2005 – 2007

2003 – 2005

2000 – 2003

1995 – 2000

1994

1992 – 1994


International Visiting Lectureships

 

Nov 2014

Sept – Oct 2013

Nov 2011

July 2011

Mar 2010

Dec 2008


Education, Training & Degrees

 

2010
  • Board Certification as Pediatric Rheumatologist ("Zusatzweiterbildung")
2009
  • Board Certification as Physician for Infectious Diseases ("Zusatzweiterbildung")
2009
  • Certification of PhD Degree Equivalency and Associate Professor Status, PhD in Bacterial Immunology
    (in accordance with official U.S. guidelines)
2009
2009,
2013 & 2016
  • Good Clinical Practice (GCP) Training Certification, Mainz, Germany
    (Initial certification followed by recertification in subsequent years)
2007

2005

  • Board Certification as Physician for Pediatrics and Adolescent Medicine ("Facharzt")

1995

1994

1994

  • Medical License ("Approbation als Arzt")

1992

  • Medical Certification ("Medizinisches Staatsexamen")

1984 – 1992

  • Medical School, Study of Human Medicine
    – Friedrich-Alexander University, Erlangen, Germany
    – Albert-Ludwig University, Freiburg, Germany
    – University of Basel, Basel, Switzerland
    – University of Cape Town, Cape Town, South Africa

Affiliations

Professional Memberships

 

DGKJ
DGPI
GKJR
ATP
ESPID
AGPRS

Grants & Fellowships

 

2014

2013

2011

2011

2010

2008

2005

1999


Publications

Original Published Research

 

Ingegnoli F, Ughi N, Dinsdale G, Orenti A, Boracchi P, Allanore Y, Foeldvari I, Sulli A, Cutolo M, Smith V, Herrick AL, EULAR Study Group on Microcirculation in Rheumatic Diseases (2017)
An international SUrvey on non‑iNvaSive tecHniques to assess the mIcrocirculation in patients with RayNaud’s phEnomenon (SUNSHINE survey).
Rheumatology International 37:1879-1890.
Abstract

Hinze CH, Holzinger D, Lainka E, Haas JP, Speth F, Kallinich T, Minden K, Rieber N, Hufnagel M, Jansson A, Hedrich C, Winowski H, Horneff G, Foell D für die PRO-KIND SJIA-Projektgruppe (2017)
Harmonization of diagnostics and therapy of systemic-onset juvenile idiopathic arthritis in Germany: Process description and key messages. [Harmonisierung der Diagnostik und Therapie der systemischen juvenilen idiopathischen Arthritis in Deutschland: Prozessbeschreibung und Kernaussagen].
Arthritis + Rheuma 37:250-259. German.
Citation

Poppert S, Heideking M, Agostini HJ, Fritzenwanker M, Wüppenhorst N, Muntau B, Henneke P, Kern WV, Krücken J, Junker B, Hufnagel M (2017)
Diffuse unilateral subacute neuroretinitis caused by Ancylostoma.
Emerging Infectious Diseases. 23;343-344.
Abstract

Albiński M, Hufnagel M, Schelling J, Fleck T, Siepe M, Zieger B, Stiller B (2016)
Cardiac thrombus with risk of fulminant pulmonary embolism in pediatric antiphospholipid syndrome.
Klinische Pädiatrie. 228:219-222.
Abstract

Klotsche J, Raab A, Niewerth M, Sengler C, Ganser G, Kallinich T, Niehues T, Hufnagel M, Thon A, Hospach T, Horneff G, Minden K (2016)
Outcome and trends in treatment of newly diagnosed patients with systemic juvenile idiopathic Arthritis in the National Pediatric Rheumatological Database from 2000 to 2013.
Arthritis & Rheumatology. 2016;68:3023-3034.
Abstract

Bielicki JA, Sharland M, Johnson AP, Henderson KL, Cromwell DA; Antibiotic Resistance and Prescribing in European Children project (2016)
(* Dr. Markus Hufnagel is a contributing member of the ARPEC (Antibiotic Prescribing and Resistance in European Children) Project.)
Selecting appropriate empirical antibiotic regimens for paediatric bloodstream infections: application of a Bayesian decision model to local and pooled antimicrobial resistance surveillance data.
Journal of Antimicrobial Chemotherapy. 71:794-802.
Abstract

Hufnagel M, König S, Theilacker C (2016)
Importance of local epidemiology in prevalence and resistance of cystic fibrosis-related pathogens.
Pediatric Infectious Diseases Journal. 35:229.
Abstract

Jakob A, Whelan J, Kordecki M, Berner R, Stiller B, Arnold R, von Kries R, Roubinis N, Robert M, Grohman J, Höhn R, Hufnagel M (2016)
Kawasaki disease in Germany: A prospective, population-based study adjusted for underreporting.
Pediatric Infectious Diseases Journal. 35:129-134.
Abstract

Grom AA, Ilowite NT, Pascual V, Brunner HI, Martini A, Lovell D, Ruperto N; Paediatric Rheumatology International Trials Organisation and the Pediatric Rheumatology Collaborative Study Group*, Leon K, Lheritier K, Abrams K (2016)
(* Dr. Markus Hufnagel is a contributing member of the Paediatric Rheumatology International Trials Organisation.)
Rate and Clinical Presentation of Macrophage Activation Syndrome in Patients With Systemic Juvenile Idiopathic Arthritis Treated With Canakinumab.
Arthritis and Rheumatology. 68:218-28.
Abstract

Spyridis N, Syridou G, Goossens H, Versporten A, Kopsidas J, Kourlaba G, Bielicki J, Drapier N, Zaoutis T, Tsolia M, Sharland M, ARPEC Project Group* (2016)
(* Dr. Markus Hufnagel is a contributing member of the ARPEC (Antibiotic Prescribing and Resistance in European Children) Project.)
Variation in paediatric hospital antibiotic guidelines in Europe.
Archives of Disease in Childhood. 101:72-6.
Abstract

Rosini R, Campisi E, De Chiara M, Tettelin H, Rinaudo D, Toniolo C, Metruccio M, Guidotti S, Skov Sørensen UB, Kilian M, Ramirez M, DEVANI Consortium*, Janulczyk R, Donati C, Grandi G, Margarit I (2015)
(* Dr. Markus Hufnagel is a contributing member of the DEVANI (Design of a Vaccine Against Neonatal Infections) Study Group.)
Genomic analysis reveals the molecular basis for capsule loss in the group B Streptococcus population.
PLoS ONE. 10:e0125985.
Abstract

Bielicki JA, Lundin R, Sharland M, for the ARPEC Project* (2015)
(* Dr. Markus Hufnagel is a contributing member of the ARPEC (Antibiotic Prescribing and Resistance in European Children) Project.)
Antibiotic resistance prevalence in routine bloodstream isolates from children’s hospitals varies substantially from adult surveillance data in Europe.
Pediatric Infectious Diseases Journal. 34:734-41.
Abstract

Lestner JM, Versporten A, Doerholt K, Warris A, Roilides E, Sharland M, Bielicki J, Goossens H, ARPEC Project Group* (2015)
(* Dr. Markus Hufnagel is a contributing member of the ARPEC (Antibiotic Prescribing and Resistance in European Children) Project.)
Systematic antifungal prescribing in neonates and children: Outcomes from the Antibiotic Resistance and Prescribing in European Children (ARPEC) study.
Antimicrobial Agents and Chemotherapy. 59:782-789.
Abstract

Kunze M, Zumstein K, Markfeld-Erol F, Elling R, Lander F, Prömpeler H, Berner R, Hufnagel M (2015)
Comparison of pre- and intrapartum screening of group B streptococci and adherence to screening guidelines: A cohort study.
European Journal of Pediatrics. 174:827–835.
Abstract

Lenz D, Held J, Goerke S, Wagner D, Tintelnot K, Henneke P, Hufnagel M (2015)
Primary cutaneous cryptococcosis in an eight-year-old immunocompetent child: how to treat?
Klinische Pädiatrie. 227:41-44. German.
Abstract

de Jong MD, Reusken C, Horby P, Koopmans M, Bonten M, Chiche JD, Giaquinto C, Welte T, Leus F, Schotsman J, Goossens H, on behalf of the PREPARE consortium and affiliated clinical networks* (2014)
(* Dr. Markus Hufnagel is a contributing member of the PREPARE Consortium.)
Preparedness for admission of patients with suspected Ebola virus disease in European hospitals: a survey, August-September 2014.
EuroSurveillance 19(48):pii=20980.
Abstract

Da Cunha V, Davies MR, Douarre PE, Rosinski-Chupin I, Margarit I, Spinali S, Perkins T, Lechat P, Dmytruk N, Sauvage E, Ma L, Romi B, Tichit M, Lopez-Sanchez MJ, Descorps-Declere S, Souche E, Buchrieser C, Trieu-Cuot P, Moszer I, Clermont D, Maione D, Bouchier C, McMillan DJ, Parkhill J, Telford JL, Dougan G, Walker MJ; DEVANI Consortium*, Holden MT, Poyart C, Glaser P (2014)
(* Dr. Markus Hufnagel is a contributing member of the DEVANI (Design of a Vaccine Against Neonatal Infections) Study Group.)
Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline.
Nature Communications. 5:4544.
Abstract

D’Urzo N, Martinelli M, Pezzicoli A, De Cesare V, Pinto V, Margarit I, Telford JL, Maione D; Members of the DEVANI Study Group* (2014)
(* Dr. Markus Hufnagel is a contributing member of the DEVANI (Design of a Vaccine Against Neonatal Infections) Study Group.)
Acidic pH strongly enhances in vitro biofilm formation by a subset of hypervirulent ST-17 Streptococcus agalactiae strains.
Applied and Environmental Microbiology. 80:2176-2185.
Abstract

Hufnagel M, Sixel K, Hammer F, Kropec A, Sava IG, Theilacker C, Berner R, Huebner J (2014)
Detection of opsonic antibodies against Enterococcus faecalis cell wall carbohydrates in immune globulin preparations.
Infection. 42:749-755.
Abstract

Puzik A, Geiger J, Hufnagel M (2014)
A young girl with familial Mediterranean fever and abdominal pain.
Clinical Pediatrics. 53:1106-1108.
Abstract

Elling R, Hufnagel M, Imm A, de Zoysa A, Lander F, Zumstein K, Kunze M, Lausch E, Krueger M, Henneke P (2014)
Synchronous recurrence of group B streptococcal late-onset sepsis in twins.
Pediatrics. 133:e1388-e1391.
Abstract

Blessing K, Toepfner N, Kinzer S, Möllmann C, Geiger J, Serr A, Hufnagel M, Müller C, Krüger M, Ridder GJ, Berner R. (2013)
Lemierre syndrome associated with 12th cranial nerve palsy: A case report and review.
International Journal of Pediatric Otorhinolaryngology. 77:1585-1588.
Abstract

Heideking M, Lander F, Hufnagel M, Pfeifer Y, Wicker E, Krause G, Berner R (2013)
Antibiotic susceptibility profiles of neonatal invasive isolates of Escherichia coli from a 2-year nationwide surveillance study in Germany, 2009–2010
European Journal of Clinical Microbiology and Infectious Diseases. 32:1221–1223.

Abstract

Simon A, Müller A, Kaiser P, Töpfner N, Berner R, Laws H-J, Knorr M, Hufnagel M, Beyersdorff A, Heister P, Becker C, Liese JG, Tenenbaum T (2013)
The Paed IC project: Antibiotic stewardship and hospital hygiene to prevent infection with resistant pathogens. [Das Paed IC Projekt: Antibiotic Stewardship und Infektionsprävention zur Vermeidung von nosokomialen Infektionen durch resistente Infektionserreger.]
Klinische Pädiatrie 225; 93-95. German.
Citation

Yao K, Poulsen K, Maione D, Rinaudo CD, Baldassarri L, Telford JL, Sørensen UBS, members of the DEVANI Study Group*, Kilian M (2013)
(* Dr. Markus Hufnagel is a contributing member of the DEVANI (Design of a Vaccine Against Neonatal Infections) Study Group.)
Capsular Gene Typing of Streptococcus agalactiae Compared to Serotyping by Latex Agglutination
Journal of Clinical Microbiology. 51(2):503-7.
Abstract

Toepfner N, Henneke P, Berner R, Hufnagel M (2012)
Impact of technical training on rapid antigen detection tests (RADT) in group A streptococcal tonsillopharyngitis
European Journal of Clinical Microbiology and Infectious Diseases, 32:609-611.
Abstract

Meinicke H, Heinzmann A, Geiger J, Berner R, Hufnagel M (2012)
Symptoms of Shrinking Lung Syndrome Reveal Systemic Lupus Erythematosus in a 12-Year-Old Girl
Pediatric Pulmonology, 48:1246–1249.
Abstract

Hufnagel M, Henneke P, Schmitt-Graeff A (2012)
IgG4-Related Disease
New England Journal of Medicine. 366:1643-44, Author reply 1646-7.
Abstract

Jakob A, Creutzfeldt R, Staszewski O, Winterpacht A, Berner R, Hufnagel M (2012)
Primary erythromalalgia in a 12-year-old boy: Positive response to sodium channel blockers despite negative SCN9A mutations.
Klinische Pädiatrie. 224:309–312.
Abstract

Farmand S, Henneke P, Hufnagel M, Berner R (2012)
Significant decline in the erythromycin resistance of group A streptococcus isolates at a German paediatric tertiary care centre.
European Journal of Clinical Microbiology and Infectious Diseases. 31:707-710.
Abstract

Jessen B, Maul-Pavicic A, Ufheil H, Vraetz T, Enders A, Lehmberg K, Längler A, Gross-Wieltsch U, Bay A, Kaya Z, Bryceson YT, Koscielniak E, Badawy S, Davies G, Hufnagel M, Schmitt-Gräff A, Aichele P, zur Stadt U, Schwarz K, Ehl S (2011)
Subtle differences in CTL cytotoxicity determine susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome.
Blood, 118:4620-4629.
Abstract

Fluegge K, Wons J, Spellerberg B, Swoboda S, Siedler A, Hufnagel M, Berner R (2011)
Genetic Differences Between Invasive and Noninvasive Neonatal Group B Streptococcal Isolate.
Pediatric Infectious Disease Journal. 30:1027-1031
Abstract

Afshar B, Broughton K, Creti R, Detcheva A, Hufnagel M, Kriz P, Lambertsen L, Lovgren M, Melin P, Orefici G, Poyart C, Radtke A, Rodriguez-Granger J, Skov Sørensen UB, Telford J, Valinsky L, Zachariadou L, Members of the DEVANI study group*, Efstratiou A. (2011)
(* Dr. Markus Hufnagel is a contributing member of the DEVANI (Design of a Vaccine Against Neonatal Infections) Study Group.)
International External Quality Assurance for Laboratory Diagnosis and Typing of Streptococcus agalactiae (group B streptococci).
Journal of Clinical Microbiology. 49:1475-1482
Abstract

Maul-Pavicic A, Chiang S, Rensing-Ehl A, Fauriat C, Hufnagel M, Schulze I, Bass T, Schamel W, Schwarz K, Bryceson Y, Ehl S (2011)
Orai1 is required for target cell-induced NK cell degranulation and cytokine production.
Proceedings of the National Academy of Science. 108:3324-3329
Abstract

Schenk T, Maier B, Hufnagel M, Strahm B, Kontny U, Neumann-Haefelin D, Falcone V (2011)
Persistence of human bocavirus DNA in immunocompromised children.
Pediatric Infectious Diseases Journal, 30:82-84
Abstract

Hatz C, Inoubli S, Loutan L, Genton B, Behrens R, Hufnagel M (2010)
Japanese encephalitis: Risk for endemic populations and for travellers. [Encéphalite japonaise: risque pour les populations vivant en zones d'endémie et pour les voyageurs.]
Revue Médicale Suisse, 6(248):956-9. French.
Abstract

Carlsson G, Hufnagel M, Jansen O, Claviez A, Nabavi A (2010)
Rapid recovery of motor and cognitive functions after resection of a right frontal lobe meningioma in a child.
Child's Nervous System, 26:105-111
Abstract

Hatz C, Werlein J, Mutsch M, Hufnagel M, Behrens RH (2009)
Japanese Encephalitis: Defining Risk Incidence for Travelers to Endemic Countries and Vaccine Prescribing From the UK and Switzerland.
Journal of Travel Medicine, 16:200-203
Abstract

von Schnakenburg C, Hufnagel M, Superti-Furga A, Rieger-Fackeldey E, Berner R (2009)
Successful Continuous Renal Replacement Therapy in a Neonate with Early-onset Group B Streptococcal Sepsis and Multi-organ Dysfunction Syndrome. [Multiorganversagen bei Early-onset-B-Streptokokkensepsis: Erfolgreicher Einsatz einer kontinuierlichen venovenösen Hämofiltration (CVVH) beim Neugeborenen.]
Klinische Pädiatrie, 221:251-3. German.
Abstract

Hufnagel M, Burger A, Bartelt S, Henneke P, Berner R (2008)
Secular trends in pediatric bloodstream infections over a 20-year period at a tertiary care hospital in Germany.
European Journal of Pediatrics, 167:1149-59
Abstract

Hufnagel M, Liese C, Löscher C, Kunze K, Prömpeler H, Berner R, Krüger M (2007)
Enterococcal colonization of infants in a neonatal intensive care unit: Seasonal patterns and associated risk factors.
BMC Infectious Diseases, 7:107
Abstract

Schenk T, Strahm B, Kontny U, Hufnagel M, Neumann-Haefelin D, Falcone V (2007)
Disseminated human bocavirus infection in a child following hematopoietic stem cell transplantation.
Emerging Infectious Diseases, 13:1425-1427
Abstract

Hufnagel M, Carey VJ, Baldassarri L, Reinert RR, Huebner J (2006)
Distribution of four capsular serotypes of Enterococcus faecalis among clinical isolates from different geographical origins and infection sites.
Infection, 34:22-25
Abstract

Buck D, Malivert L, de Chasseval R, Barraud A, Fondanèche M-C, Sanal O, Plebani A, Stèphan J-L, Hufnagel M, le Deist F, Fischer A, Durandy A, de Villartay JP, Revy P (2006)
Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly.
Cell, 124:287-299
Abstract

Hufnagel M, Czech N, Schmidt M, Hero B, Claviez A (2006)
Neuroblastoma Stage 4S with 123I-MIBG-positive bone marrow involvement.
Pediatric Blood & Cancer, 46:264-265
Citation

Hufnagel M, Huebner J (2005)
Analysis of the specific immune response against capsular polysaccharides of two patients with systemic enterococcal infections.
Infection, 33:373-376
Abstract

Kropec A, Hufnagel M, Zimmermann K, Huebner J (2005)
In vitro assessment of the host response against Enterococcus faecalis in probiotic preparations.
Infection, 33:377-379
Abstract

Hufnagel M, Kropec A, Theilacker C, Huebner J (2005)
Naturally acquired antibodies against four Enterococcus faecalis capsular polysaccharides in normal human sera.
Clinical and Vaccine Immunology (formerly Clinical and Diagnostic Laboratory Immunology), 12:930-934
Abstract

Hufnagel M, Hancock LE, Koch S, Theilacker C, Gilmore MS, Huebner J (2004)
Serological and genetic diversity of capsular polysaccharides in Enterococcus faecalis.
Journal of Clinical Microbiology, 42:2548-2557
Abstract

Hufnagel M, Koch S, Creti R, Baldassarri L, Huebner J (2004)
A putative sugar-binding transcriptional regulator in a novel gene locus in Enterococcus faecalis contributes to biofilm formation and prolonged bacteremia in mice.
Journal of Infectious Diseases, 189:420-430
Abstract

Hufnagel M, Koch S, Kropec A, Huebner J (2003)
Opsonophagocytic assay as a potentially useful tool for assessing safety of Enterococcal preparation.
International Journal of Food Microbiology, 88:263-267
Abstract

Lässker U, Harder TC, Hufnagel M, Suttorp M (2002)
Rapid molecular discrimination of infection with wild-type varicella zoster virus or varicella vaccine virus.
Infection, 30:320-322
Abstract

Harder TC, Hufnagel M, Zahn K, Beutel K, Schmitt HJ, Ullmann U, Rautenberg P (2001)
A new LightCycler™ polymerase chain reaction for rapid and sensitive quantification of parvovirus B19 DNA guides therapeutic decision-making in chronic infections.
Journal of Clinical Microbiology, 39:4413-4419
Abstract

Eichmann D, Hufnagel M, Quick P, Santer R (1999)
Treatment of hyperinsulinemic hypoglycemia with nifedipine.
European Journal of Pediatrics, 158:204-206
Abstract

Muller D, Hufnagel M, Suttorp (1999)
Accidental overdose of vancomycin in preterm twins.
Pediatric Infectious Diseases Journal, 18:744-745
Citation

Hufnagel M, Eichmann D, Stieh J, Santer R (1998)
Further evidence for a dominant form of familial persistent hyperinsulinemic hypoglycemia of infancy: a family with documented hyperinsulinemia in two generations.
Journal of Clinical Endocrinology and Metabolism, 83:2215-2216
Citation

Dai WJ, Bartens W, Kohler G, Hufnagel M, Kopf M, Brombacher F (1997)
Impaired macrophage listericidal and cytokine activities are responsible for the rapid death of Listeria monocytogenes-infected IFN-gamma receptor-deficient mice.
Journal of Immunology, 158:5297-5304.
Abstract

Hufnagel M, Niemeyer C, Zimmerhackl LB, Tuchelmann T, Sauter S, Brandis M (1995)
Hemophagocytosis: a complication of acute Q fever in a child.
Clinical Infectious Diseases, 21:1029-1031.
Abstract

Hufnagel M, Tuchelmann, Zimmerhackl LB, Leititis JU, Tüchelmann T, Brandis M, Brem S, Schindera F (1994)
Acute renal failure without liver involvement in Leptospirosis icterohaemorrhagiae infection. [Akutes Nierenversagen ohne Leberbeteiligung bei Leptospira icterohaemorrhagiae-Infektion.]
Monatsschrift Kinderheilkunde 142:957-960. German.

Citation


Medical Reviews

 

Pfeil J, Hufnagel M (2017)
Rational diagnostics and therapies in child refugees.
Pediatric Infectious Disease Journal. (On press)
Citation

Simon A, von Both U, Hufnagel M, Hübner J (2017)
Antibiotic stewardship in pediatric medicine.
[Antibiotic Stewardship in der Kinder- und Jugendmedizin.]

Monatsschrift Kinderheilkunde (On press). German.
Citation

Simon A, von Both U, Hufnagel M, Hübner J (2017)
Antibiotic stewardship in pediatric medicine.
[Antibiotic Stewardship in der Kinder- und Jugendmedizin.]

Deutsche Arzteblatt (On press). German.
Citation

Hufnagel M (2017)
Readmission after pertussis infections (real-life questions and answers).
[Wiederzulassung nach/bei Pertussis-Infektion (Fragen & Antworten aus der Praxis).]

Pädiatrische Praxis 87:553-4. German.
Citation

Simon A, Tenenbaum T, Huppertz HI, Trapp S, Prelog M, Hufnagel M, Knuf M, Rose MA, Forster J, Nicolai T, Berger C, Nadal D, Hübner J, Berner R, Liese J (2017)
Diagnosis and therapy of respiratory tract infections (without community-acquired pneumonia) in pediatric outpatients without severe underlying diseases.
[Diagnose und Therapie von Atemwegsinfektionen (ohne ambulant erworbene Pneumonie) bei ambulant behandelten Kindern ohne schwerwiegende Grunderkrankung.]

Monatsschrift Kinderheilkunde. Online first. German.
Citation

Jakob A, Hufnagel M (2017)
Steroid therapy and Kawasaki disease: Validity of current studies (Reader Forum).
[Steroidtherapie und Kawasaki-Syndrom: Aussagekraft vorliegender Studien (Leserforum).]

Monatsschrift Kinderheilkunde 165:184-5. German.
Citation

Simon A, Tenenbaum T, Huppertz HI, Trapp S, Prelog M, Hufnagel M, Knuf M, Rose MA, Forster J, Nicolai T, Berger C, Nadal D, Hubner J, Berner R, Liese J (2016)
Respiratory tract infections in children: When are antibiotics indicated — and when not.
[Atemwegsinfektionen bei Kindern: Wann Antibiotika indiziert sind – und wann nicht.]

Deutsches Ärzteblatt 113(21):[14]; DOI: 10.3238/PersInfek.2016.05.27.04. German.
Citation

Kobbe R, Kitz C, Trapp S, Pfeil J, Hufnagel M (2016)
Care of child refugees: Emphasis on diagnostics and prevention of infectious diseases.
[Versorgung von minderjährigen Flüchtlingen: Schwerpunkt Diagnostik und Prävention von Infektionskrankheiten.]

Notfall + Rettungsmedizin. 19:346-54. German.
Citation

Hufnagel M (2016)
Second vaccinations against measles, mumps and rubella after the 15th month of life: Real-life questions and answers. [Zweitimpfung gegen Masern, Mumps, Röteln ab dem 15. Lebensmonat: Fragen & Antworten aus der Praxis.]
Pädiatrische Praxis. 86:183-5. German.
Citation

von Both U, Simon A, Hufnagel M, Hübner J (2016)
Antibiotic Stewardship in der Pädiatrie. [Antibiotic Stewardship in Pediatrics].
Kinder- und Jugendarzt. 47:212-20. German.
Citation

Pfeil J, Kobbe R, Trapp S, Kitz C, Hufnagel M (2016)
Empfehlungen zur infektiologischen Versorgung von Flüchtlingen im Kindes- und Jugendalter in Deutschland: Stellungnahme der Deutschen Gesellschaft für Pädiatrische Infektiologie, der Gesellschaft für Tropenpädiatrie und Internationale Kindergesundheit und des Berufsverbandes der Kinder- und Jugendärzte.
[Recommendations for the diagnosis and prevention of infectious diseases in pediatric and adolescent refugees in Germany: Statement of the German Society of Pediatric Infectious Diseases, the Society of Tropical Pediatrics and International Child Health, and the Professional Association of Pediatricians].

Internist 57:416-33. German.
Abstract

Simon A, Agyeman P, Amman R, Attarbashi A, Behrends U, Berger C, Groll AH, Hamprecht A, Hufnagel M, Laws HJ, Lehrnbecher T (2016)
AWMF S2k guideline of the Germany Society for Pediatric Infectious Diseases (DGPI) and the Society of Pediatric Oncology and Hematology (GPOH).
[AWMF S2k Leitlinie der Deutschen Gesellschaft für pädiatrische Infektiologie (DGPI) und Gesellschaft Pädiatrische Onkologie und Hämatologie (GPOH)].
Diagnostics and therapy in children with oncological underlying diseases, fever and granulocytopenia (febrile neutropenia), excluding children with allogenic stem cell transplantation.
[Diagnostik und Therapie bei Kindern mit onkologischer Grunderkrankung, Fieber und Granulozytopenie (mit febriler Neutropenie) außerhalb der allogenen Stammzelltransplantation.]

AWMF registration number 048/14, Version 23 Jan. 2016. German.
Citation

Bosk A, Groll A, Hufnagel M, Lehrnbecher T, Pöschl J, Simon A, Wendt C (2015)
AWMF S2k guidelines of the Germany Society for Pediatric Infectious Diseases (DGPI) and other German medical societies.
[AWMF S2k Leitlinie der Deutschen Gesellschaft für pädiatrische Infektiologie (DGPI) und anderer deutscher medizinischer Gesellschaften].
Sepsis in children beyond the neonatal period. [Sepsis bei Kindern jenseits der Neonatalperiode.]
AWMF registration number 024/25, Version December 2015. German.
Citation

Pfeil J, Kobbe R, Trapp S, Kitz C, Hufnagel M (2016)
Versorgung von Flüchtlingen: Diagnostik und Prävention im Kindes- und Jugendalter.
[Medical care of refugees: Diagnostics and prevention in children and adolescents].

Deutsches Ärzteblatt. 113:A134-6. German.
Abstract

Pfeil J, Kobbe R, Trapp S, Kitz C, Hufnagel M (2015)
Empfehlungen zur infektiologischen Versorgung von Flüchtlingen im Kindes- und Jugendalter in Deutschland. Stellungnahme der Deutschen Gesellschaft für Pädiatrische Infektiologie, der Gesellschaft für Tropenpädiatrie und Internationale Kindergesundheit und des Berufsverbandes der Kinder- und Jugendärzte.
[Recommendations for the diagnosis and prevention of infectious diseases in pediatric and adolescent refugees in Germany. Statement of the German Society of Pediatric Infectious Diseases, the Society of Tropical Pediatrics and International Child Health, and the Professional Association of Pediatricians].

Monatsschrift Kinderheilkunde. 163:1269–1286. German.
Abstract

Ritz N, Hufnagel M, Gérardin P (2015).
Chikungunya in children.
Pediatric Infectious Diseases Journal. 34:789-91.
Abstract

Strothmann JML, Henneke P, Hufnagel M (2013)
IgG4-related disease (IgG4-RD) – also a childhood disease. [IgG4-related disease (IgG4-RD) – auch eine Erkrankung des Kindesalters.]
Arthritis + Rheuma. 33:317-322. German.
Abstract

Elling R, Henneke P, Hatz C, Hufnagel M (2013)
Dengue fever in children: Where are we now?
Pediatric Infectious Disease Journal. 32:1020-1022.
Citation

Bode SFN, Hufnagel M, Speckmann C (2012)
Vaccination under immunosuppression and in immunocompromised patients. [Impfungen bei Immunsuppression und bei immunkompromittierten Patienten.]
Pädiatrische Praxis. 79:647-657. German.
Citation

Elling R, Kontny U, Henneke P, Hufnagel M (2012)
Clinical evaluation of peripheral lymph node swelling in children. [Abklärung peripherer Lymphknotenvergrößerungen im Kindesalter.]
Monatsschrift Kinderheilkunde. 160:901-918. German.
Abstract

Elling R, Hufnagel M, Henneke P (2012)
Skin bleeding associated with infection. [Infektionsassoziierte Hautblutungen.]
Monatsschrift Kinderheilkunde. 160:545–555. German.
Abstract

Rodriguez-Granger J, Alvargonzalez JC, Berardi A, Berner R, Kunze M, Hufnagel M, Melin P, Decheva A, Orefici G, Poyart C, Telford J, Efstratiou A, Killian K, Krizova P, Baldassarri L, Spellerberg S, Puertas A and Rosa-Fraile M. (2012)
Prevention of group B streptococcal neonatal disease revisited: The DEVANI European Project.
European Journal of Clinical Microbiolology and Infectious Diseases. 31:20972104.
Abstract

Kenzel S, Hufnagel M, Berner R, Henneke P (2010)
Pneumococcus Vaccination and Serotype Replacement: Do we need a new vaccine or vaccination concept? [Pneumokokkenimpfung und Serotyp-Replacement: Brauchen wir ein neues Impf(stoff)konzept?.]
Deutsche Medizinische Wochenschrift 135:1198-1200. German.
Abstract

Lander F, Hufnagel M, Berner R (2010)
Antimicrobial therapy for sepsis in pediatrics. [Antimikrobielle Therapie der Sepsis in der Pädiatrie.]
Pädiatrische Praxis 75:233-245. German.
Citation

Weih M, Schaller G, Degirmenci U, Hufnagel M, Kornhuber J (2009)
Differential diagnosis of neurodegenerative disorders in young adults. [Differentialdiagnosen zu neurodegenerativen Erkrankungen im jungen Erwachsenenalter.]
Fortschritte der Neurologie-Psychiatrie 77(11):662-668. German.
Citation

Hufnagel M, Berner R (2009)
Lymphadenitis colli – a guideline for diagnostic and therapeutic procedures. [Lymphadenitis colli – ein Leitfaden für das diagnostische und therapeutische Vorgehen.]
Kinder- und Jugendarzt. 40:300-11. German.
Citation

Hufnagel M, Henneke P, Krüger M, Berner R (2008)
Severe, rapid-onset sepsis in childhood. [Die foudroyante Sepsis im Kindesalter.]
Up2date Notfallmedizin, 3:149-171. German.

Citation

Hufnagel M, Burger A, Zwigart M, Berner R (2008)
Epidemiology of Staphylococcus aureus bacteremia in childhood – "secular trends". [Epidemiologie von Staphylococcus aureus-Bakteriämien im Kindesalter – "säkulare Trends."]
Kinder- und Jugendmedizin, 8:88-92. German.
Citation

Hufnagel M, Berner R (2007)
Lice, fleas and other beasts. [Läuse, Flöhe und anderes Getier.]
Kinderkrankenschwester, 26:283-8. German.
Citation

Hufnagel M, Neef V, Berner R (2007)
White tongue in Infants – not always oral thrush. [Die weiße Zunge beim Säugling – nicht immer ein Mundsoor.]
Kinderärztliche Praxis 78:152-154. German.

Abstract

Koch S, Hufnagel M, Huebner J (2004)
Treatment and prevention of enterococcal infections – alternative and experimental approaches.
Expert Opinion on Biological Therapy, 4:1519-31
Abstract

Koch S, Hufnagel M, Theilacker C, Huebner J (2004)
Enterococcal infections: host response, therapeutic, and prophylactic possibilities.
Vaccine, 22:822–830
Abstract

Hufnagel M (2001)
Hand, mouth, foot disease. [Hand-Mund-Fuß-Krankheit.]
Deutsche Medizinische Wochenschrift, 126:1125-1126. German.
Citation

Hufnagel M, Schmitt HJ (1999)
Acute fever in travelers returning from the tropics. [Akutes Fieber bei Tropenrückkehrern.]
Kinderärztliche Praxis 7:496-503. German.
Citation

Hufnagel M, Schmitt HJ (1999)
Chronic fever in travelers returning from the tropics. [Chronisches Fieber bei Tropenrückkehrern.]
Kinderärztliche Praxis 7:504-509. German.

Citation


Medical Textbook Contributions

 

Hufnagel M, Schmitt HJ (2014, 2007, 2003, 2001)
Chlamydia Infections. [Chlamydien-Infektionen.]
Chapter in "Pädiatrie Grundlagen und Praxis, [Pediatric Fundamentals and Practice]," eds. Hoffmann GF, Lentze MJ, Spranger J, Zepp F. Springer-Verlag Berlin, pp. 889-891. German.
Reference

Hufnagel M, Schmitt HJ (2014, 2007, 2003, 2001)
Q-Fever. [Q-Fieber.]
Chapter in "Pädiatrie Grundlagen und Praxis,[Pediatric Fundamentals and Practice]," eds. Hoffmann GF, Lentze MJ, Spranger J, Zepp F. Springer-Verlag Berlin, pp. 895-896. German.
Reference

Hufnagel M, Schmitt HJ (2014, 2007, 2003, 2001)
Sepsis. [Sepsis.]
Chapter in "Pädiatrie Grundlagen und Praxis, [Pediatric Fundamentals and Practice]," eds. Hoffmann GF, Lentze MJ, Spranger J, Zepp F. Springer-Verlag Berlin, pp. 842-848. German.
Reference

Hufnagel M, Schmitt HJ (2014, 2007, 2003, 2001)
Toxic Shock Syndrome. [Toxisches Schocksyndrom.]
Chapter in "Pädiatrie Grundlagen und Praxis, [Pediatric Fundamentals and Practice]," eds. Hoffmann GF, Lentze MJ, Spranger J, Zepp F. Springer-Verlag Berlin, pp. 849-851. German.
Reference

Zepp F, Schmitt HJ, Hufnagel M (2014, 2007, 2003, 2001)
Typhoid and Cholera Vaccination. [Typhus- und Choleraschutzimpfung.]
Chapter in "Pädiatrie Grundlagen und Praxis, [Pediatric Fundamentals and Practice]," eds. Hoffmann GF, Lentze MJ, Spranger J, Zepp F. Springer-Verlag Berlin, pp. 132-133. German.
Reference

Nicolai T, Hübner J, Hufnagel M, Schaad UB, Wirbelauer J (2013)
Sepsis. [Sepsis.]
Chapter in “Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]”, ed. Deutsche Gesellschaft für Pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp 776-784. German.
Reference

Hübner J, Hufnagel M (2013)
Peritonitis [Peritonitis].
Chapter in “Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]”, ed. Deutsche Gesellschaft für Pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp 773-775. German.
Reference

Hübner J, Arweiler N, Hufnagel M (2013)
Odontogenic Infections [Odontogene Infektionen]
Chapter in “Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]”, ed. Deutsche Gesellschaft für Pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp 768-772. German.
Reference

Herting E, Hufnagel M, Kunze M, Spellerberg B, Roos R, Berner R (2013)
Infections by β-hemolytic group B (GBS) streptococci [Infektionen durch β-hämolysierende Streptokokken der Gruppe B (GBS)]
Chapter in “Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]”, ed. Deutsche Gesellschaft für Pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp 517-520. German.
Reference

Bialek R, Bernard H, Hufnagel M (2013)
Q-Fever [Q-Fieber]
Chapter in “Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]”, ed. Deutsche Gesellschaft für Pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp 463-465. German.
Reference

Hufnagel M, Knuf M (2013, 2009, 2003, 2000)
Leptospirosis. [Leptospirose.]
Chapter in "Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]," ed. Deutsche Gesellschaft für pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp. 369-371. German.
Reference

Hufnagel M, Lemmen S, Simon A (2013, 2009, 2003, 2000)
Legionella. [Legionellose.]
Chapter in "Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]," ed. Deutsche Gesellschaft für pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp. 358-360. German.
Reference

Hufnagel M, [H-R Brodt], Panning M, Ritz N (2013)
Viral Hemorrhagic Fevers [Hämorrhagische Fieber durch Viren]
Chapter in “Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]”, ed. Deutsche Gesellschaft für Pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp 275-283. German.
Reference

Hufnagel M, Heininger U, Hübner J (2013)
Enterococcal Infections [Enterokokken-Infektionen]
Chapter in “Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]”, ed. Deutsche Gesellschaft für Pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp 242-253. German.
Reference

Hufnagel M, Panning M (2013)
Dengue Fever [Dengue-Fieber]
Chapter in “Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]”, ed. Deutsche Gesellschaft für Pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp 281-221. German.
Reference

Ritz N, Hufnagel M (2013)
Chikungunya Fever [Chikungunya-Fieber]
Chapter in “Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]”, ed. Deutsche Gesellschaft für Pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp 195-196. German.
Reference

Huppertz HI, Hufnagel M, Niehues T (2013)
Infectious Prophylaxis in Immune-modulating Drug Therapy [Infektionsprophylaxe bei immunmodulatorischer Therapie]
Chapter in “Handbuch Infektionen bei Kindern und Jugendlichen, [Handbook of Infectious Diseases in Children and Adolescents]”, ed. Deutsche Gesellschaft für Pädiatrische Infektiologie. Georg Thieme Verlag Stuttgart, pp 129-131. German.
Reference

Hufnagel M (2008)
Pneumococcus: The Clinical Picture. [Pneumokokken: Das Krankheitsbild.]
Chapter in "Konjugatimpfstoffe und Infektionskrankheiten durch bekapselte Erreger." [Conjugate Vaccines and Infectious Diseases Caused by Capsulated Microorganisms],
ed. Berner R. Uni-Med Science, 1:25-35. German.

Reference


Keywords

 

  • Pediatrics, Pediatric Medicine, Infectious Diseases, Infectious Disease Specialist, Pediatric Rheumatology, Rheumatologist, Immunology, Tropical Medicine, Travel Medicine, Vaccinology, vaccines, Freiburg, University Clinic, Research
  • Pädiatrie, pädiatrische Medizin, Kindermedizin, Jugendmedizin, Kinderarzt, Arzt, Infektiologie, Infektiologue, pädiatrische Rheumatologie, Rheumatologue, Immunologie, Tropenmedizin, Reisemedizin, Vakzinologie, Impfungen, Freiburg, Uniklinik, Uniklinikum, Forschung

Contact

 

Dr. Markus Hufnagel
Center for Pediatrics and Adolescent Medicine, Clinic I
Division of Pediatric Infectious Diseases and Rheumatology
University Medical Center Freiburg

Mathildenstr. 1
D-79106 Freiburg
Germany

Tel: +49 (0)761-270-43000
Fax: +49 (0)761-270- 44730
Email:
Website: markushufnagel.com