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Level and correlates of physical activity among children and adolescents with juvenile idiopathic arthritis compared to controls: Results from a German nationwide prospective observational cohort study.

Milatz F, Hansmann S, Klotsche J, Niewerth M, Kallinich T, Dressler F, Haas JP, Berendes R, Horneff G, Hufnagel M, Weller-Heinemann F, Windschall D, Trauzeddel R, Klaas M, Girschick H, Oomen PT, Foeldvari I, Cantez MS, Jansson AF, Hartmann M, Peitz-Kornbrust J, Minden K (2024).
Level and correlates of physical activity among children and adolescents with juvenile idiopathic arthritis compared to controls: Results from a German nationwide prospective observational cohort study. .
Pediatric Rheumatology 22:39 DOI: 10.1186/s12969-024-00976-2 Language: English
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2024-03-20T23:56:50+02:00Categories: Original research|Tags: , , |

Principles of rational antibiotic therapy. Antibiotic stewardship in the outpatient sector

Antibiotic use in pediatric acute care hospitals: an analysis of antibiotic consumption data from Germany, 2013-2020

Freudenhammer M, Hufnagel M, Steib-Bauert M, Mansmann U, de With K, Fellhauer M, Kern WV (2023).
Antibiotic use in pediatric acute care hospitals: an analysis of antibiotic consumption data from Germany, 2013-2020.
Infection 51:6 DOI: 10.1007/s15010-023-02112-w Language: English
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2023-11-12T00:12:20+02:00Categories: Original research|Tags: , , |

Discrepancies between national and local guidelines for the management of pediatric oncology patients with fever and neutropenia (FN): a need for alignment?

Spielberger B, Hufnagel M, Reifenrath K, Simon A, Last K, Papan C (2023).
Discrepancies between national and local guidelines for the management of pediatric oncology patients with fever and neutropenia (FN): a need for alignment?.
EJC Paediatric Oncology 2:100030 DOI: 10.1016/j.ejcped.2023.100030 Language: English
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2023-11-07T00:30:54+02:00Categories: Original research|Tags: , , , |

Therapy-refractory course of extended-oligoarticular juvenile idiopathic arthritis

2023-10-15T21:27:54+02:00Categories: Original research|Tags: , |

Antimicrobial use in pediatric oncology and hematology: a cross-sectional, multi-center point-prevalence study with a multi-step qualitative adjudication process

Papan C, Reifenrath K, Last K, Attarbaschi Andishe A, Graf N, Groll AH, Hübner J, Laws HJ, Lehrnbecher T, Liese JG, Martin L, Tenenbaum T, Vieth S, von Both U, Wagenpfeil G, Weichert S, Hufnagel M, Simon A (2023).
Antimicrobial use in pediatric oncology and hematology: a cross-sectional, multi-center point-prevalence study with a multi-step qualitative adjudication process.
Lancet Regional Health - Europe DOI: 10.1016/j.lanepe.2023.100599 Language: English
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2023-11-07T00:30:28+02:00Categories: Original research|Tags: , , |

Secukinumab in enthesitis-related arthritis and juvenile psoriatic arthritis: a randomised, double-blind, placebo-controlled, treatment withdrawal, phase 3 trial

Brunner HI, Foeldvari I, Alexeeva E, Ayaz NA, Calvo Penades I, Kasapcopur O, Chasnyk VG, Hufnagel M, Zuber Z, Schulert GS, Ozen S, Rakhimyanova A, Ramanan A, Scott C, Sozeri B, Zholobova E, Martin R, Zhu X, Whelan S, Pricop L, Martini A, Lovell DJ and Ruperto N, on behalf of Paediatric Rheumatology INternational Trials Organization (PRINTO) and Pediatric Rheumatology Collaborative Study Group (PRCSG) (2023).
Secukinumab in enthesitis-related arthritis and juvenile psoriatic arthritis: a randomised, double-blind, placebo-controlled, treatment withdrawal, phase 3 trial.
Annals of Rheumatic Diseases 82:154-60 DOI: 10.1136/ard-2022-222849 Language: English
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2023-10-16T16:43:40+02:00Categories: Original research|Tags: , , |

Neonatal invasive disease caused by Streptococcus agalactiae in Europe: the DEVANI multi-center study

Lohrmann F, Hufnagel M, Kunze M, Afshar B, Creti R, Detcheva A, Kozakova J, Rodriguez-Granger J, Skov Sørensen UB, Margarit I, Maione D, Rinaudo D, Orefici G, Telford J, de la Rosa Fraile M, Kilian M, Efstratiou A, Berner R, Melin P, for the DEVANI study group (2022).
Neonatal invasive disease caused by Streptococcus agalactiae in Europe: the DEVANI multi-center study.
Infection 51(4):981-991 DOI: 10.1007/s15010-022-01965-x Language: English
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2023-11-07T00:31:31+02:00Categories: Original research|Tags: , , |

Development of inflammatory bowel disease in children with juvenile idiopathic arthritis treated with biologics

Broehaert IJ, Klein A, Windschall D, Rogalski B, Weller-Heinemann F, Oommen P, Küster M, Foeldvari I, Minden K, Hospach A, Hufnagel M, Berger T, Geikowski T, Quietzsch J, Horneff G (2022).
Development of inflammatory bowel disease in children with juvenile idiopathic arthritis treated with biologics.
Journal of Pediatric Gastroenterology and Nutrition 76(2):174-182 DOI: 10.1097/MPG.0000000000003656 Language: English
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2023-10-16T16:36:42+02:00Categories: Original research|Tags: , , |

Study protocol for a multi-center point-prevalence study with qualitative expert panel assessment of antimicrobial use in pediatric oncology and hematology

Papan C, Reifenrath K, Last K, Attarbaschi A, Graf N, Groll AH, Hübner J, Laws HJ, Lehrnbecher T, Liese J, Martin L, Tenenbaum T, Weichert S, Vieth S, von Both U, Hufnagel M, Simon A, for the Study Group "Antibiotic Stewardship" of the DGPI and the Study Group "Febrile Neutropenia" of the GPOH (2022).
Study protocol for a multi-center point-prevalence study with qualitative expert panel assessment of antimicrobial use in pediatric oncology and hematology.
JMIR Research Protocols 11:e35774 DOI: 10.2196/35774 Language: English
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Cross-sectional seroprevalence surveys of SARS-CoV-2 antibodies in children in Germany, June 2020 to May 2021

Sorg AL, Bergfeld L, Jank M, Corman V, Semmler I, Görtz A, Beyerlein A, Verjans E, Wagner N, von Bernuth H, Lander F, Weil K, Hufnagel M, Spiekerkoetter U, Cho-Ming C, Nährlich L, Muntau AC, Schulze-Sturm U, Hansen G, Wetzke M, Jung AM, Niehues T, Fricke-Otto S, von Both U, Huebner J, Behrends U, Liese JG, Schwerk C, Drosten C, von Kries R, Schroten H (2022).
Cross-sectional seroprevalence surveys of SARS-CoV-2 antibodies in children in Germany, June 2020 to May 2021.
Nature Communications 13(1):3128 DOI: 10.1038/s41467-022-30482-6 Language: English
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Infectious diseases-related health care based upon the example of Ukrainian refugees

Spielberger B, Pfeil J, Assaad K, von Both U, Janda A, Kitz C, Kobbe R, Kunze M, Lindert J, Ritz N, Trapp S, Hufnagel M (2022).
Infectious diseases-related health care based upon the example of Ukrainian refugees. Infektiologische Versorgung minderjähriger Flüchtlinge am Beispiel der Ukraine
Monatsschrift Kinderheilkunde 170:1103-12 DOI: 10.1007/s00112-022-01607-4 Language: German
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2023-10-15T21:16:39+02:00Categories: Medical reviews|Tags: , , |

Recommendation for standardized medical care for children and adolescents with long COVID

Töpfner N, Alberer M, Ankermann T, Bender S, Berner R, de Laffolie J, Dingemann J, Heinicke D, Haas J-P, Hufnagel M, Hummel T, Huppertz H-I, Knuf M, Kobbe R, Lücke T, Riedel J, Rosenecker J, Wölfle J; Schneider B, Schneider D, Schriever V, Schroeder A, Stojanov S, Tenenbaum T, Trapp S, Vilser D, Brinkmann F, Behrends U (2022).
Recommendation for standardized medical care for children and adolescents with long COVID. Einheitliche Basisversorgung von Kindern und Jugendlichen mit Long COVID. Stellungnahme einer multidisziplinären Arbeitsgruppe der DGKJ-Konvent-Gesellschaften (Stand: Februar 2022)
Monatsschrift Kinderheilkunde 170:539-547 DOI: 10.1007/s00112-021-01408-1 Language: German
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2023-10-16T17:33:19+02:00Categories: Medical reviews|Tags: , , , |

Screening for tuberculosis among refugee children and adolescents from Ukraine. A recommendation of the German Central Committee against Tuberculosis e.V. (DZK), together with the writing group pediatric tuberculosis of the Society of Pediatric Pneumology (GPP)

2023-10-15T21:16:50+02:00Categories: Medical reviews|Tags: , , , |

Updated recommendations on the treatment of infectious diseases in refugees in childhood and adolescence in Germany (situation as of 30 March 2022), registered as S1 guidelines (AWMF-Register Nr. 048-017). Statement of the German Society for Pediatric Infectious Diseases (DGPI e.V.), the Society for Tropical Pediatrics and International Child Health (GTP e.V.), the Professional Association of Doctors in Pediatric and Adolescent Medicine (BVKJ e.V.), and the German Society for Pediatric and Adolescent Medicine (DGKJ e.V.)

2023-10-16T16:32:01+02:00Categories: Medical guidelines|Tags: , , |

First year follow-up of children with chronic non-bacterial osteomyelitis – and analysis of the German National Pediatric Rheumatologic Database 2009-2018

Reiser C, Klotsche J, Hospach T, Berendes R, Schnabel A, Jansson A, Hufnagel M, Groesch N, Niewerth M, Minden K, Girschick H (2021).
First year follow-up of children with chronic non-bacterial osteomyelitis – and analysis of the German National Pediatric Rheumatologic Database 2009-2018.
Arthritis Research & Therapy 23:281 DOI: 10.1186/s13075-021-02658-w Language: English
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2023-10-15T21:29:49+02:00Categories: Original research|Tags: , |

High diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of pediatric pulmonary tuberculosis

Geweniger A, Janda A, Eder K, Fressle R, Kannan CV, Fahnenstich H, Elze M, Müller C, Henneke P, Hufnagel M, Elling R (2021).
High diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of pediatric pulmonary tuberculosis.
BMC Infectious Diseases 21:946 DOI: 10.1186/s12879-021-06413-z Language: English
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Improving empiric antibiotic prescribing in pediatric bloodstream infections: a potential application of weighted-incidence syndromic combination antibiograms (WISCA)

Cook A, Sharland M, Yau Y, PediBSI Group, Bielicki J. (* Dr. Markus Hufnagel is a contributing member of the PediBSI Study Group) (2021).
Improving empiric antibiotic prescribing in pediatric bloodstream infections: A potential application of weighted-incidence syndromic combination antibiograms (WISCA).
Expert Reviews of Anti-Infective Therapy 20(3):445-456 DOI: 10.1080/14787210.2021.1967145 Language: English
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Case report: Lymphohistiocytic myocarditis with severe cardiogenic shock requiring mechanical cardiocirculatory support in Multisystem Inflammatory Syndrome following SARS-CoV-2 infection

Bemtgen X, Klingel K, Hufnagel M, Janda A, Bode C, Staudacher DL, Supady A, Jandova I (2021).
Case report: Lymphohistiocytic myocarditis with severe cardiogenic shock requiring mechanical cardiocirculatory support in Multisystem Inflammatory Syndrome following SARS-CoV-2 infection.
Frontiers in Cardiovascular Medicine 8:716198 DOI: 10.3389/fcvm.2021.716198 Language: English
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Reduction of outpatient antibiotic prescriptions for children and adolescents in Germany 2010-2019

2023-10-15T21:30:15+02:00Categories: Original research|Tags: , , |

Aetiology of acute respiratory tract infection in pre-school children requiring hospitalisation in Europe – results from the PED-MERMAIDS multi-centre case-control study

Kohns Vasconcelos M, Loens K, Sigfrid L, Iosifidis E, Epalza C, Dona D, Papachristou S, Roilides E, Gijon M, Rojo P, Minotti C, Da Dalt L, Islam S, Jarvis J, Syggelou A, Tsolia M, Nyirenda Nyang'wa M, Keers S, Renk H, Gemmel AL, D'Amore C, Ciofi degli Atti M, Rodriguez-Tenreiro Sanchez C, Martinon-Torres F, Burokiene S, Goetghebuer T, Spoulou V, Riordan A, Calvo C, Gkentzi D, Hufnagel M, Openshaw P, Goossens H, Leven G, Fraaij P, Giaquinto C, Bielicki JA, Horby P, Sharland M (2021).
Aetiology of acute respiratory tract infection in pre-school children requiring hospitalisation in Europe – results from the PED-MERMAIDS multi-centre case-control study.
BMJ Open Respiratory Research 8:e000887 DOI: 10.1136/bmjresp-2021-000887 Language: English
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2023-10-15T21:30:20+02:00Categories: Original research|Tags: , |

Prevalence of Capsular Serotype, Pilus Island Distribution, and Antibiotic Resistance in Pediatric and Adult Invasive Group B Streptococcus Isolates: Data From a Nationwide Prospective Surveillance Study in Germany

Lohrmann F, Berg A, Wicker E, Imm A, Krause G, Zürn K, Berner R, Hufnagel M, Lander F (2021).
Prevalence of Capsular Serotype, Pilus Island Distribution, and Antibiotic Resistance in Pediatric and Adult Invasive Group B Streptococcus Isolates: Data From a Nationwide Prospective Surveillance Study in Germany.
Pediatric Infectious Diseases 40:76-82 DOI: 10.1097/INF.0000000000002943 Language: English
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SARS-CoV-2 testing and infection control strategies in European paediatric emergency departments during the first wave of the pandemic

Kohns Vasconcelos M, Renk H, Popielska J, Nyirenda Nyang'wa M, Burokiene S, Gkentzi D, Gowin E, Donà D, Villanueva-Medina S, Riordan A, Hufnagel M, Eisen S, Da Dalt L, Giaquinto C, Bielicki JA (2021).
SARS-CoV-2 testing and infection control strategies in European paediatric emergency departments during the first wave of the pandemic.
European Journal of Pediatrics 180:1299-1305 DOI: 10.1007/s00431-020-03843-w Language: English
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Subcutaneous dosing regimen of tocilizumab in children with systemic or polyarticular juvenile idiopathic arthritis

Ruperto N, Brunner H, Ramanan A, Horneff G, Cuttica R, Henrickson M, Lopez JA, Boteanu AL, Calvo Penades I, Minden K, Schmeling H, Hufnagel M, Weiss JE, Pardeo M, Nanda A, Roth J, Rubio-Perez N, Hsu JC, Wimalasundera S, Wells C, Bharucha K, Douglass W, Bao M, Mallalieu NL, Martini A, Lovell D, De Benedetti F for the Paediatric Rheumatology International Trial Organization (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG). (* Dr. Markus Hufnagel is a contributing member of the PRINTO Study Group) (2021).
Subcutaneous dosing regimen of tocilizumab in children with systemic or polyarticular juvenile idiopathic arthritis.
Rheumatology 60:4568-4580 DOI: 10.1093/rheumatology/keab047 Language: English
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2023-10-15T21:30:35+02:00Categories: Original research|Tags: , , |

Tapering Canakinumab Monotherapy in Patients with Systemic Juvenile Idiopathic Arthritis in Clinical Remission: Results from an Open-label, Randomized Phase IIIb/IV Study

Quartier P, Alexeeva E, Tamàs C, Chasnyk V, Wulffraat N, Palmblad K, Wouters C, Brunner H, Marzan K, Schneider R, Horneff G, Martini A, Anton J, Wei X, Slade A, Ruperto N, Abrams K; Pediatric Rheumatology International Trials Organization (PRINTO), the Pediatric Rheumatology Collaborative Study Group (PRCSG). (* Dr. Markus Hufnagel is a contributing member of the PRINTO Study Group) (2021).
Tapering Canakinumab Monotherapy in Patients with Systemic Juvenile Idiopathic Arthritis in Clinical Remission: Results from an Open-label, Randomized Phase IIIb/IV Study.
Arthritis Rheumatology 73:336-346 DOI: 10.1002/art.41488 Language: English
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2023-10-15T21:31:19+02:00Categories: Original research|Tags: , , |

Evaluation of serum osteopontin levels as biomarkers for children with Kawasaki disease

Jakob A, Schachinger E, Klau S, Hufnagel M, van der Werf Grohmann N, Stiller B, Lehner A, Ulrich S (2020).
Evaluation of serum osteopontin levels as biomarkers for children with Kawasaki disease.
Annals of Cardiology and Vascular Medicine 3:1035 DOI: 10.3389/fped.2019.00242 Language: English
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2023-10-15T21:31:24+02:00Categories: Original research|Tags: , , |

Anakinra and etanercept combination treatment in a child with severe, non-responsive Kawasaki disease

Walser M, Hermann M, Hufnagel M, Haas NA, Fischer M, Dalla-Pozza R, Jakob A (2020).
Anakinra and etanercept combination treatment in a child with severe, non-responsive Kawasaki disease.
Pediatric Infectious Diseases Journal 39:e310-e313 DOI: 10.1097/INF.0000000000002810 Language: English
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2023-10-15T21:31:29+02:00Categories: Original research|Tags: , , |

Hospital admission in children and adolescents with COVID-19—early results from a national survey conducted by the German Society for Pediatric Infectious Diseases (DGPI)

Microarray analysis of Group B streptococci causing invasive neonatal early- and late-onset infection

Zürn K, Lander F, Hufnagel M, Monecke S, Berner R (2020).
Microarray analysis of Group B streptococci causing invasive neonatal early- and late-onset infection.
Pediatric Infectious Diseases Journal 39:449-453 DOI: 10.1097/INF.0000000000002627 Language: English
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Comprehensive infectious disease screening in a cohort of unaccompanied refugee minors in Germany from 2016 to 2017: A cross-sectional study

Janda A, Eder K, Fressle R, Geweniger A, Diffloth N, Heeg M, Binder N, Sitaru A, Rohr J, Henneke P, Hufnagel M, Elling R (2020).
Comprehensive infectious disease screening in a cohort of unaccompanied refugee minors in Germany from 2016 to 2017: A cross-sectional study.
PLoS Medicine 17(3): e1003076 DOI: 10.1371/journal.pmed.1003076 Language: English
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2023-10-15T21:31:45+02:00Categories: Original research|Tags: , , , |

Season, sex and surgery: Risk factors for complicated lymphadenitis caused by non-tuberculous mycobacteria in children

Kuntz M, Kohlfürst DS, Feiterna-Sperling C, Krüger R, Baumann U, Buchtala L, Elling R, Grote V, Hübner J, Hufnagel M, Kaiser-Labusch P, Liese J, Otto EM, Rose MA, Schneider C, Schuster V, Seidl M, Sommerburg O, Vogel M, von Bernuth H, Weiß M, Zimmermann T, Nieters A, Zenz W, and Henneke P for the NTMkids consortium (2020).
Season, sex and surgery: Risk factors for complicated lymphadenitis caused by non-tuberculous mycobacteria in children.
Emerging Infectious Diseases 26:579-586 DOI: 10.3201/eid2603.191388 Language: English
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Long-term surveillance of biologic therapies in systemic-onset juvenile idiopathic arthritis. Data from the German BIKER registry

Klein A, Klotsche J, Hügle B, Minden K, Hospach A, Weller-Heinemann F, Schwarz T, Dressler F, Trauzeddel R, Hufnagel M, Foeldvari I, Borte M, Kuemmerle-Deschner J, Brunner J, Oommen PT, Föll D, Tenbrock K, Urban A, Horneff G (2020).
Long-term surveillance of biologic therapies in systemic-onset juvenile idiopathic arthritis. Data from the German BIKER registry.
Rheumatology 59:2287-2298 DOI: 10.1093/rheumatology/kez577 Language: English
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2023-10-15T21:31:56+02:00Categories: Original research|Tags: , , |

Standard antibiotic treatment of frequent infectious diseases in outpatient pediatrics. Recommendations of the working group on antibiotic stewardship in outpatient pediatrics (ABSaP) of the German Society for Pediatric Infectious Diseases (DGPI), the Professional Association of Pediatric and Adolescent Physicians (BVKJ) and the Bielefeld Initiative AnTiB

2023-10-15T21:17:04+02:00Categories: Medical reviews|Tags: , , |

Diagnosis and treatment of Guillain-Barré Syndrome in childhood and adolescence: An evidence- and consensus-based guideline

Korinthenberg R, Trollmann R, Felderhoff-Müser U, Bernert G, Hackenberg A, Hufnagel M, Pohl M, Hahn G, Mentzel HJ, Sommer C, Lambeck J, Mecher F, Hessenauer M, Winterholler C, Kempf U, Jacobs BC, Rostasy K, Müller-Felber W (2020).
Diagnosis and treatment of Guillain-Barré Syndrome in childhood and adolescence: An evidence- and consensus-based guideline.
European Journal of Pediatric Neurology 25:5-16 DOI: 10.1016/j.ejpn.2020.01.003 Language: English
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2023-11-07T00:48:42+02:00Categories: Medical guidelines|Tags: |

Long-term, single-center surveillance of non-invasive group A streptococcal (GAS) infections, emm types and emm clusters

Konrad P, Hufnagel M, Berner R, Töpfner N (2019).
Long-term, single-center surveillance of non-invasive group A streptococcal (GAS) infections, emm types and emm clusters.
European Journal of Clinical Microbiology and Infectious Diseases 39:273-280 DOI: 10.1007/s10096-019-03719-4 Language: English
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Intravenous Artesunate for Imported Severe Malaria in Children Treated in Four Tertiary Care Centers in Germany: A Retrospective Study

Bélard S, Brand J, Schulze-Sturm U, Janda A, von Both U, Tacoli C, Alberer M, Kempf C, Stegemann MS, Krüger R, Varnholt V, Blohm M, Reiter K, Zoller T, Suttorp N, Mall M, von Bernuth H, Gratopp A, Hübner J, Hufnagel M, Kobbe R, Kurth F (2019).
Intravenous Artesunate for Imported Severe Malaria in Children Treated in Four Tertiary Care Centers in Germany: A Retrospective Study.
Pediatric Infectious Diseases Journal 38:e295-e300 DOI: 10.1097/INF.0000000000002417 Language: English
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Epidemiology of Human Parechovirus Type 3 Upsurge in 2 Hospitals, Freiburg, Germany, 2018

Elling R, Böttcher S, du Bois F, Müller A, Prifert C, Weissbrich B, Hofmann J, Korn K, Eis-Hübinger A-M, Hufnagel M, Panning M (2019).
Epidemiology of Human Parechovirus Type 3 Upsurge in 2 Hospitals, Freiburg, Germany, 2018.
Emerging Infectious Diseases 25:1384-1388 DOI: 10.3201/eid2507.190257 Language: English
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2023-10-15T21:32:46+02:00Categories: Original research|Tags: , , |

Using the WHO Access/Watch/Reserve classification to define patterns of hospital antibiotic use: analysis of pediatric point prevalence survey data from 56 countries. The first AWaRe PPS

Hsia Y, Lee BR, Versporten A, Yang Y, Bielicki J, Jackson C, Newland J, Goossens H, Magrini N, Sharland M on behalf of the GARPEC and Global-PPS networks. (*Dr. Hufnagel is a contributing member of the GARPEC and Global-PPS networks) (2019).
Using the WHO Access/Watch/Reserve classification to define patterns of hospital antibiotic use: analysis of pediatric point prevalence survey data from 56 countries. The first AWaRe PPS.
Lancet Global Health 7:e861-871 DOI: 10.1016/S2214-109X(19)30071-3 Language: English
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American College of Rheumatology Provisional Criteria for Clinically Relevant Improvement in Children and Adolescents With Childhood-Onset Systemic Lupus Erythematosus

Brunner HI, Holland MJ, Beresford MW, Ardoin SP, Appenzeller S, Silva CA, Flores F, Goilav B, Avar Aydin PO, Wenderfer SE, Levy DM, Ravelli A, Khubchandani R, Avcin T, Klein-Gitelman MS, Ruperto N, Feldman BM, Ying J; Paediatric Rheumatology International Trial Organisation and Pediatric Rheumatology Collaborative Study Group. (*Dr. Hufnagel is a contributing member of the Paediatric Rheumatology International Trial Organization) (2019).
American College of Rheumatology Provisional Criteria for Clinically Relevant Improvement in Children and Adolescents With Childhood-Onset Systemic Lupus Erythematosus.
Arthritis Care & Research 71:579-90 DOI: 10.1002/acr.23834 Language: English
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2023-10-15T21:32:56+02:00Categories: Original research|Tags: , |

Breastfeeding and vitamin D supplementation reduce the risk of Kawasaki disease in a German population-based case-control study

Meyer K, Volkmann A, Hufnagel M, Schachinger E, Klau S, Horstmann J, Berner R, Fischer M, Lehner A, Haas N, Ulrich S, Jakob A (2019).
Breastfeeding and vitamin D supplementation reduce the risk of Kawasaki disease in a German population-based case-control study.
BMC Pediatrics 26;19(1):66 DOI: 10.1186/s12887-019-1438-2 Language: English
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2023-10-15T21:33:01+02:00Categories: Original research|Tags: , , |

High rates of prescribing for prophylaxis in children and neonates: Results from the Antibiotic Resistance and Prescribing in European Children Point Prevalance Survey (ARPEC-PPS)

Hufnagel M, Versporten A, Bielicki J, Drapier N, Sharland M, Goossens H, for the ARPEC Project Group (2019).
High rates of prescribing for prophylaxis in children and neonates: Results from the Antibiotic Resistance and Prescribing in European Children Point Prevalance Survey (ARPEC-PPS).
Journal of the Pediatriatric Infectious Disease Society 8:143-151 DOI: 10.1093/jpids/piy019 Language: English
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Antibiotic stewardship – Conception and implementation in the inpatient pediatric medicine: A new AWMF S2k guideline (AWMF registration number 048/15) coordinated by the German Society for Pediatric Infectious Diseases

2023-10-16T16:32:17+02:00Categories: Medical guidelines|Tags: , |

Diagnosis and treatment of Guillain-Barré Syndrome in children and adolescents

Korinthenberg R, Felderhoff U, Bernert G, Hackenberg A, Hufnagel M, Hahn G, Winterholler C, Pohl M, Rostasy K, Müller-Felber W, Kempf U, Meerpohl J, Mentzel HJ, Hessenauer M. Lambeck J, Jacobs BC, Sommer C (2019).
Diagnosis and treatment of Guillain-Barré Syndrome in children and adolescents. Diagnose und Therapie des Guillain-Barré Syndroms im Kindes- und Jugendalter
AWMF S3 Leitlinie registration number 022/008 DOI: Language: German
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2023-11-07T00:35:06+02:00Categories: Medical guidelines|Tags: |

Recommendations for Diagnostics and Therapy of Children with Cancer Presenting with Fever and Neutropenia – Comparison of Two Current Guidelines

Lehrnbecher T, Groll AH, Agyeman P, Amman RA, Attarbaschi A, Behrends U, Berger C, Hamprecht A, Hufnagel M, Laws HJ, Scheler M, Temme C, Vieth S, Simon A für die Arbeitsgemeinschaften "Infektionen" der GPOH und "Fieber bei Neutropenie" der DGPI (2018).
Recommendations for Diagnostics and Therapy of Children with Cancer Presenting with Fever and Neutropenia - Comparison of Two Current Guidelines. Empfehlungen zur Diagnostik und Therapie bei krebskranken Kindern mit Fieber und Granulozytopenie - Vergleich zweier aktueller Leitlinien
Klinische Pädiatrie 230:115-121 DOI: 10.1055/s-0044-101953 Language: German
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2023-11-07T00:35:31+02:00Categories: Original research|Tags: , , , |

Cystic encephalomalacia following vasculopathy and vasospasm of proximal intracranial arteries due to pneumococcal meningitis in a young infant

Pschibul A, Janzarik WG, Franck P, Hufnagel M, Beck C, Korinthenberg R (2018).
Cystic encephalomalacia following vasculopathy and vasospasm of proximal intracranial arteries due to pneumococcal meningitis in a young infant.
Neuropediatrics 49:213-216 DOI: 10.1055/s-0038-1635075 Language: English
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2023-10-15T21:33:20+02:00Categories: Original research|Tags: , |

Failure to predict high risk Kawasaki disease patients in a population-based study cohort in Germany

Jakob A, von Kries R, Horstmann J, Hufnagel M, Stiller B, Berner R, Schachinger E, Meyer K, Obermeier V (2018).
Failure to predict high risk Kawasaki disease patients in a population-based study cohort in Germany.
Pediatric Infectious Disease Journal 37:850-855 DOI: 10.1097/INF.0000000000001923 Language: English
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2023-10-15T21:33:25+02:00Categories: Original research|Tags: , , |

Protocols for classification, monitoring and therapy in pediatric rheumatology (PRO-KIND): Chronic non-bacterial osteomyelitis (CNO)

Schwarz T, Oommen PT, Windschall D, Weissbarth-Riedel E, Trauzeddel R, Grote V, von Bismarck P, Morbach H, Hofmann C, Holl-Wieden A, Hügle B, Schnabel A, Dedeoglu F, Ferguson PJ, Zhao Y, Borte M, Haas JP, Hufnagel M, Hedrich CM, Girschick HJ, Jansson AF für die PRO-KIND CNO-Projektgruppe (2018).
Protocols for classification, monitoring and therapy in pediatric rheumatology (PRO-KIND): Chronic non-bacterial osteomyelitis (CNO). HarmProtokolle zur Klassifikation, Überwachung und Therapie in der Kinderrheumatologie (PRO-KIND): Chronisch nicht-bakterielle Osteomyelitis (CNO)
Arthritis + Rheuma 38:282-288 DOI: 10.1055/s-0038-1669796 Language: German
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2023-10-15T21:33:30+02:00Categories: Original research|Tags: , |

Practice and consensus-based diagnostic strategies in diagnosing and managing systemic juvenile idiopathic arthritis in Germany

Hinze CH, Holzinger D, Lainka E, Haas JP, Speth F, Kallinich T, Rieber N, Hufnagel M, Jansson A, Hedrich C, Winowski H, Berger T, Foeldvari I, Ganser G, Hospach T, Huppertz H-I, Mönkemöller K, Neudorf U, Weißbarth-Riedel E, Wittkowski H, Horneff G, Foell D; PRO-KIND SJIA project (2018).
Practice and consensus-based diagnostic strategies in diagnosing and managing systemic juvenile idiopathic arthritis in Germany.
Pediatric Rheumatology Online Journal 16:7 DOI: 10.1186/s12969-018-0224-2 Language: English
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2023-10-15T21:34:11+02:00Categories: Original research|Tags: , , |

Lymphadenitis colli infections

Elling R, Hufnagel M, Laws HJ, Nadal D, Ritz N (2018).
Lymphadenitis colli infections. (Lymphadenitis colli-Infektionen)
Chapter(s) in "DGPI Handbuch: Infektionen bei Kindern und Jugendlichen" ("DGPI Handbook of Infectious Diseases in Children and Adolescents"), eds. Deutsche Gesellschaft für Pädiatrische Infektiologie (DGPI). Georg Thieme Verlag, Stuttgart, pp. 207-212. ISBN: 9783132408142. Language: German.
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2024-04-13T14:34:46+02:00Categories: Medical textbook contributions|Tags: , |

Sepsis after the neonatal period

Nicolai T, Agyeman P, Hübner J, Hufnagel M, Schaad UB, Wirbelauer J (2018, 2013).
Sepsis after the neonatal period. (Sepsis jenseits der Neonatalperiode)
Chapter(s) in "DGPI Handbuch: Infektionen bei Kindern und Jugendlichen" ("DGPI Handbook of Infectious Diseases in Children and Adolescents"), eds. Deutsche Gesellschaft für Pädiatrische Infektiologie (DGPI). Georg Thieme Verlag, Stuttgart, pp. 292-296. ISBN: 9783132408142. Language: German.
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2024-04-13T14:36:08+02:00Categories: Medical textbook contributions|Tags: , |

Odontogenic infections, gingivitis and periodontitis

Hübner J, Arweiler N, Hufnagel M, Kühnisch J (2018, 2013).
Odontogenic infections, gingivitis and periodontitis. (Odontogene Infektionen, Gingivitis und Parodontitis)
Chapter(s) in "DGPI Handbuch: Infektionen bei Kindern und Jugendlichen" ("DGPI Handbook of Infectious Diseases in Children and Adolescents"), eds. Deutsche Gesellschaft für Pädiatrische Infektiologie (DGPI). Georg Thieme Verlag, Stuttgart, pp. 201-206. ISBN: 9783132408142. Language: German.
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Group B streptococcus infections (GBS)

Lander F, Berner R, Herting E, Hufnagel M, Kunze M, Spellerberg B (2018, 2013).
Group B streptococcus infections (GBS). (Streptokokken-Gruppe B-Infektionen (GBS))
Chapter(s) in "DGPI Handbuch: Infektionen bei Kindern und Jugendlichen" ("DGPI Handbook of Infectious Diseases in Children and Adolescents"), eds. Deutsche Gesellschaft für Pädiatrische Infektiologie (DGPI). Georg Thieme Verlag, Stuttgart, pp. 759-763. ISBN: 9783132408142. Language: German.
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Leptospirosis

Hufnagel M, Knuf M (2018, 2013, 2009, 2003, 2000).
Leptospirosis. (Legionellose)
Chapter(s) in "DGPI Handbuch: Infektionen bei Kindern und Jugendlichen" ("DGPI Handbook of Infectious Diseases in Children and Adolescents"), eds. Deutsche Gesellschaft für Pädiatrische Infektiologie (DGPI). Georg Thieme Verlag, Stuttgart, pp. 596-598. ISBN: 9783132408142. Language: German.
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Legionella

Hufnagel M, Lemmen SW, Lück C (2018, 2013, 2009, 2003, 2000).
Legionella. (Legionellose)
Chapter(s) in "DGPI Handbuch: Infektionen bei Kindern und Jugendlichen" ("DGPI Handbook of Infectious Diseases in Children and Adolescents"), eds. Deutsche Gesellschaft für Pädiatrische Infektiologie (DGPI). Georg Thieme Verlag, Stuttgart, pp. 584-586. ISBN: 9783132408142. Language: German.
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Viral Hemorrhagic Fevers

Hufnagel M, Kitz C, Panning M, Schmiedel S (2018, 2013).
Viral Hemorrhagic Fevers. (Hämorrhagische Fieber durch Viren)
Chapter(s) in "DGPI Handbuch: Infektionen bei Kindern und Jugendlichen" ("DGPI Handbook of Infectious Diseases in Children and Adolescents"), eds. Deutsche Gesellschaft für Pädiatrische Infektiologie (DGPI). Georg Thieme Verlag, Stuttgart, pp. 496-505. ISBN: 9783132408142. Language: German.
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Enterococcal Infections

Hufnagel M, Heininger U, Hübner J (2018, 2013).
Enterococcal Infections. (Enterokokken-Infektionen)
Chapter(s) in "DGPI Handbuch: Infektionen bei Kindern und Jugendlichen" ("DGPI Handbook of Infectious Diseases in Children and Adolescents"), eds. Deutsche Gesellschaft für Pädiatrische Infektiologie (DGPI). Georg Thieme Verlag, Stuttgart, pp. 460-463. ISBN: 9783132408142. Language: German.
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Dengue Fever

Hufnagel M, Panning M (2018, 2013).
Dengue Fever. (Dengue-Fieber)
Chapter(s) in "DGPI Handbuch: Infektionen bei Kindern und Jugendlichen" ("DGPI Handbook of Infectious Diseases in Children and Adolescents"), eds. Deutsche Gesellschaft für Pädiatrische Infektiologie (DGPI). Georg Thieme Verlag, Stuttgart, pp. 435-438. ISBN: 9783132408142. Language: German.
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Chikungunya Fever

Ritz N, Hufnagel M (2018, 2013).
Chikungunya Fever. (Chikungunya-Fieber)
Chapter(s) in "DGPI Handbuch: Infektionen bei Kindern und Jugendlichen" ("DGPI Handbook of Infectious Diseases in Children and Adolescents"), eds. Deutsche Gesellschaft für Pädiatrische Infektiologie (DGPI). Georg Thieme Verlag, Stuttgart, pp. 409-410. ISBN: 9783132408142. Language: German.
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Infection prophylaxis for special risks: Immunomodulatory therapy

Huppertz HI, Hufnagel M, Niehues T, Urschel S (2018, 2013).
Infection prophylaxis for special risks: Immunomodulatory therapy. (Infektionsprophylaxe bei speziellen Risiken: Immunmodulatorische Therapie)
Chapter(s) in "DGPI Handbuch: Infektionen bei Kindern und Jugendlichen" ("DGPI Handbook of Infectious Diseases in Children and Adolescents"), eds. Deutsche Gesellschaft für Pädiatrische Infektiologie (DGPI). Georg Thieme Verlag, Stuttgart, pp. 140-143. ISBN: 9783132408142. Language: German.
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2024-04-13T14:35:16+02:00Categories: Medical textbook contributions|Tags: , , |

An international SUrvey on non‑iNvaSive tecHniques to assess the mIcrocirculation in patients with RayNaud's phEnomenon (SUNSHINE survey)

Ingegnoli F, Ughi N, Dinsdale G, Orenti A, Boracchi P, Allanore Y, Foeldvari I, Sulli A, Cutolo M, Smith V, Herrick AL, EULAR Study Group on Microcirculation in Rheumatic Diseases (2017).
An international SUrvey on non‑iNvaSive tecHniques to assess the mIcrocirculation in patients with RayNaud's phEnomenon (SUNSHINE survey).
Rheumatology International 37:1879-1890 DOI: 10.1007/s00296-017-3808-0 Language: English
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2023-10-16T16:41:47+02:00Categories: Original research|Tags: , |

Harmonization of diagnostics and therapy of systemic-onset juvenile idiopathic arthritis in Germany: Process description and key messages

Hinze CH, Holzinger D, Lainka E, Haas JP, Speth F, Kallinich T, Minden K, Rieber N, Hufnagel M, Jansson A, Hedrich C, Winowski H, Horneff G, Foell D für die PRO-KIND SJIA-Projektgruppe (2017).
Harmonization of diagnostics and therapy of systemic-onset juvenile idiopathic arthritis in Germany: Process description and key messages. Harmonisierung der Diagnostik und Therapie der systemischen juvenilen idiopathischen Arthritis in Deutschland: Prozessbeschreibung und Kernaussagen
Arthritis + Rheuma 37:250-259 DOI: 10.1055/s-0037-1618435 Language: German
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2023-10-15T21:34:23+02:00Categories: Original research|Tags: , , |

Diffuse unilateral subacute neuroretinitis caused by Ancylostoma

Poppert S, Heideking M, Agostini HJ, Fritzenwanker M, Wüppenhorst N, Muntau B, Henneke P, Kern WV, Krücken J, Junker B, Hufnagel M (2017).
Diffuse unilateral subacute neuroretinitis caused by Ancylostoma.
Emerging Infectious Diseases 23:343-344 DOI: 10.3201/eid2302.142064 Language: English
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Diagnosis and therapy of respiratory tract infections (without community-acquired pneumonia) in pediatric outpatients without severe underlying diseases

Simon A, Tenenbaum T, Huppertz HI, Trapp S, Prelog M, Hufnagel M, Knuf M, Rose MA, Forster J, Nicolai T, Berger C, Nadal D, Hübner J, Berner R, Liese J (2017).
Diagnosis and therapy of respiratory tract infections (without community-acquired pneumonia) in pediatric outpatients without severe underlying diseases. Diagnose und Therapie von Atemwegsinfektionen (ohne ambulant erworbene Pneumonie) bei ambulant behandelten Kindern ohne schwerwiegende Grunderkrankung
Monatsschrift Kinderheilkunde 165:711–724 DOI: Language: German
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2023-10-15T21:17:25+02:00Categories: Medical reviews|Tags: , |

Outcome and trends in treatment of newly diagnosed patients with systemic juvenile idiopathic arthritis in the National Pediatric Rheumatological Database from 2000 to 2013

Klotsche J, Raab A, Niewerth M, Sengler C, Ganser G, Kallinich T, Niehues T, Hufnagel M, Thon A, Hospach T, Horneff G, Minden K (2016).
Outcome and trends in treatment of newly diagnosed patients with systemic juvenile idiopathic arthritis in the National Pediatric Rheumatological Database from 2000 to 2013.
Arthritis & Rheumatology 68:3023-3034 DOI: 10.1002/art.39796 Language: English
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2023-10-15T21:34:38+02:00Categories: Original research|Tags: , , |

Selecting appropriate empirical antibiotic regimens for paediatric bloodstream infections: application of a Bayesian decision model to local and pooled antimicrobial resistance surveillance data

Bielicki JA, Sharland M, Johnson AP, Henderson KL, Cromwell DA; Antibiotic Resistance and Prescribing in European Children project. (* Dr. Markus Hufnagel is a contributing member of the ARPEC (Antibiotic Prescribing and Resistance in European Children) Project) (2016).
Selecting appropriate empirical antibiotic regimens for paediatric bloodstream infections: application of a Bayesian decision model to local and pooled antimicrobial resistance surveillance data.
Journal of Antimicrobial Chemotherapy 71:794-802 DOI: 10.1093/jac/dkv397 Language: English
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Kawasaki disease in Germany: A prospective, population-based study adjusted for underreporting

Jakob A, Whelan J, Kordecki M, Berner R, Stiller B, Arnold R, von Kries R, Roubinis N, Robert M, Grohman J, Höhn R, Hufnagel M (2016).
Kawasaki disease in Germany: A prospective, population-based study adjusted for underreporting.
Pediatric Infectious Diseases Journal 35:129-134 DOI: 10.1097/INF.0000000000000953 Language: English
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2023-10-15T21:34:55+02:00Categories: Original research|Tags: , , |

Rate and Clinical Presentation of Macrophage Activation Syndrome in Patients With Systemic Juvenile Idiopathic Arthritis Treated With Canakinumab

Grom AA, Ilowite NT, Pascual V, Brunner HI, Martini A, Lovell D, Ruperto N; Paediatric Rheumatology International Trials Organisation and the Pediatric Rheumatology Collaborative Study Group*, Leon K, Lheritier K, Abrams K. (* Dr. Markus Hufnagel is a contributing member of the Paediatric Rheumatology International Trials Organisation) (2016).
Rate and Clinical Presentation of Macrophage Activation Syndrome in Patients With Systemic Juvenile Idiopathic Arthritis Treated With Canakinumab.
Arthritis and Rheumatology 68:218-28 DOI: 10.1002/art.39407 Language: English
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Variation in paediatric hospital antibiotic guidelines in Europe

Spyridis N, Syridou G, Goossens H, Versporten A, Kopsidas J, Kourlaba G, Bielicki J, Drapier N, Zaoutis T, Tsolia M, Sharland M, ARPEC Project Group. (* Dr. Markus Hufnagel is a contributing member of the ARPEC (Antibiotic Prescribing and Resistance in European Children) Project) (2016).
Variation in paediatric hospital antibiotic guidelines in Europe.
Archives of Disease in Childhood 101:72-6 DOI: 10.1136/archdischild-2015-308255 Language: English
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2023-10-15T21:35:40+02:00Categories: Original research|Tags: , , |

Respiratory tract infections in children: When are antibiotics indicated — and when not

Simon A, Tenenbaum T, Huppertz HI, Trapp S, Prelog M, Hufnagel M, Knuf M, Rose MA, Forster J, Nicolai T, Berger C, Nadal D, Hubner J, Berner R, Liese J (2016).
Respiratory tract infections in children: When are antibiotics indicated — and when not. Atemwegsinfektionen bei Kindern: Wann Antibiotika indiziert sind – und wann nicht
Deutsches Ärzteblatt 113(21):[14] DOI: 10.3238/PersInfek.2016.05.27.04 Language: German
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Care of child refugees: Emphasis on diagnostics and prevention of infectious diseases

2023-10-15T21:18:45+02:00Categories: Medical reviews|Tags: , , , |

Second vaccinations against measles, mumps and rubella after the 15th month of life: Real-life questions and answers

2023-10-15T21:18:50+02:00Categories: Medical reviews|Tags: |

Recommendations for the diagnosis and prevention of infectious diseases in pediatric and adolescent refugees in Germany

2023-10-15T21:19:04+02:00Categories: Medical reviews|Tags: , , , , |

Diagnostics and therapy in children with oncological underlying diseases, fever and granulocytopenia (febrile neutropenia), excluding children with allogenic stem cell transplantation. AWMF S2k guideline of the Germany Society for Pediatric Infectious Diseases (DGPI) and the Society of Pediatric Oncology and Hematology (GPOH)

2023-11-07T00:36:49+02:00Categories: Medical guidelines|Tags: , |

Sepsis in children beyond the neonatal period

2023-10-15T21:19:09+02:00Categories: Medical reviews|Tags: , |

Genomic analysis reveals the molecular basis for capsule loss in the group B Streptococcus population

Rosini R, Campisi E, De Chiara M, Tettelin H, Rinaudo D, Toniolo C, Metruccio M, Guidotti S, Skov Sørensen UB, Kilian M, Ramirez M, DEVANI Consortium*, Janulczyk R, Donati C, Grandi G, Margarit I. (* Dr. Markus Hufnagel is a contributing member of the DEVANI (Design of a Vaccine Against Neonatal Infections) Study Group) (2015).
Genomic analysis reveals the molecular basis for capsule loss in the group B Streptococcus population.
PLoS ONE 10:e0125985 DOI: 10.1371/journal.pone.0125985 Language: English
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Antibiotic resistance prevalence in routine bloodstream isolates from children's hospitals varies substantially from adult surveillance data in Europe

Bielicki JA, Lundin R, Sharland M, for the ARPEC Project. (* Dr. Markus Hufnagel is a contributing member of the ARPEC (Antibiotic Prescribing and Resistance in European Children) Project) (2015).
Antibiotic resistance prevalence in routine bloodstream isolates from children's hospitals varies substantially from adult surveillance data in Europe.
Pediatric Infectious Diseases Journal 34:734-41 DOI: 10.1097/INF.0000000000000652 Language: English
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Systematic antifungal prescribing in neonates and children: Outcomes from the Antibiotic Resistance and Prescribing in European Children (ARPEC) study

Lestner JM, Versporten A, Doerholt K, Warris A, Roilides E, Sharland M, Bielicki J, Goossens H, ARPEC Project Group. (* Dr. Markus Hufnagel is a contributing member of the ARPEC (Antibiotic Prescribing and Resistance in European Children) Project) (2015).
Systematic antifungal prescribing in neonates and children: Outcomes from the Antibiotic Resistance and Prescribing in European Children (ARPEC) study.
Antimicrobial Agents and Chemotherapy 59:782-789 DOI: 10.1128/AAC.04109-14 Language: English
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Comparison of pre- and intrapartum screening of group B streptococci and adherence to screening guidelines: A cohort study

Kunze M, Zumstein K, Markfeld-Erol F, Elling R, Lander F, Prömpeler H, Berner R, Hufnagel M (2015).
Comparison of pre- and intrapartum screening of group B streptococci and adherence to screening guidelines: A cohort study.
European Journal of Pediatrics 174:827–835 DOI: 10.1007/s00431-015-2548-y Language: English
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Recommendations for the diagnosis and prevention of infectious diseases in pediatric and adolescent refugees in Germany. Statement of the German Society of Pediatric Infectious Diseases, the Society of Tropical Pediatrics and International Child Health, and the Professional Association of Pediatricians

Preparedness for admission of patients with suspected Ebola virus disease in European hospitals: a survey, August-September 2014

de Jong MD, Reusken C, Horby P, Koopmans M, Bonten M, Chiche JD, Giaquinto C, Welte T, Leus F, Schotsman J, Goossens H, on behalf of the PREPARE consortium and affiliated clinical networks. (* Dr. Markus Hufnagel is a contributing member of the PREPARE Consortium) (2014).
Preparedness for admission of patients with suspected Ebola virus disease in European hospitals: a survey, August-September 2014.
EuroSurveillance 19(48):pii=20980 DOI: 10.2807/1560-7917.es2014.19.48.20980 Language: English
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Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline

Da Cunha V, Davies MR, Douarre PE, Rosinski-Chupin I, Margarit I, Spinali S, Perkins T, Lechat P, Dmytruk N, Sauvage E, Ma L, Romi B, Tichit M, Lopez-Sanchez MJ, Descorps-Declere S, Souche E, Buchrieser C, Trieu-Cuot P, Moszer I, Clermont D, Maione D, Bouchier C, McMillan DJ, Parkhill J, Telford JL, Dougan G, Walker MJ; DEVANI Consortium*, Holden MT, Poyart C, Glaser P. (* Dr. Markus Hufnagel is a contributing member of the DEVANI (Design of a Vaccine Against Neonatal Infections) Study Group) (2014).
Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline.
Nature Communications 5:4544 DOI: 10.1038/ncomms5544 Language: English
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Acidic pH strongly enhances in vitro biofilm formation by a subset of hypervirulent ST-17 Streptococcus agalactiae strains

D'Urzo N, Martinelli M, Pezzicoli A, De Cesare V, Pinto V, Margarit I, Telford JL, Maione D; Members of the DEVANI Study Group* (* Dr. Markus Hufnagel is a contributing member of the DEVANI (Design of a Vaccine Against Neonatal Infections) Study Group) (2014).
Acidic pH strongly enhances in vitro biofilm formation by a subset of hypervirulent ST-17 Streptococcus agalactiae strains..
Applied and Environmental Microbiology 80:2176-2185 DOI: 10.1128/AEM.03627-13 Language: English
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Detection of opsonic antibodies against Enterococcus faecalis cell wall carbohydrates in immune globulin preparations

Hufnagel M, Sixel K, Hammer F, Kropec A, Sava IG, Theilacker C, Berner R, Huebner J (2014).
Detection of opsonic antibodies against Enterococcus faecalis cell wall carbohydrates in immune globulin preparations.
Infection 42:749-755 DOI: 10.1007/s15010-014-0628-y Language: English
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Typhoid and Cholera Vaccination

Zepp F, Schmitt HJ, Hufnagel M (2014, 2007, 2003, 2001).
Typhoid and Cholera Vaccination. (Typhus- und Choleraschutzimpfung)
Chapter(s) in "Pädiatrie Grundlagen und Praxis" ("Pediatric Fundamentals and Practice"), eds. Hoffmann GF, Lentze MJ, Spranger J, Zepp F. Springer Verlag, Berlin, pp. 132-133. ISBN: 9783642418655. Language: German.
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Lemierre syndrome associated with 12th cranial nerve palsy: A case report and review

Blessing K, Toepfner N, Kinzer S, Möllmann C, Geiger J, Serr A, Hufnagel M, Müller C, Krüger M, Ridder GJ, Berner R (2013).
Lemierre syndrome associated with 12th cranial nerve palsy: A case report and review.
International Journal of Pediatric Otorhinolaryngology 77:1585-1588 DOI: 10.1016/j.ijporl.2013.05.030 Language: English
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2023-10-16T16:37:38+02:00Categories: Original research|Tags: , |

Antibiotic susceptibility profiles of neonatal invasive isolates of Escherichia coli from a 2-year nationwide surveillance study in Germany, 2009–2010

Heideking M, Lander F, Hufnagel M, Pfeifer Y, Wicker E, Krause G, Berner R (2013).
Antibiotic susceptibility profiles of neonatal invasive isolates of Escherichia coli from a 2-year nationwide surveillance study in Germany, 2009–2010.
European Journal of Clinical Microbiology and Infectious Diseases 32:1221–1223 DOI: 10.1007/s10096-013-1871-3 Language: English
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The Paed IC project: Antibiotic stewardship and hospital hygiene to prevent infection with resistant pathogens

Simon A, Müller A, Kaiser P, Töpfner N, Berner R, Laws H-J, Knorr M, Hufnagel M, Beyersdorff A, Heister P, Becker C, Liese JG, Tenenbaum T (2013).
The Paed IC project: Antibiotic stewardship and hospital hygiene to prevent infection with resistant pathogens. Das Paed IC Projekt: Antibiotic Stewardship und Infektionsprävention zur Vermeidung von nosokomialen Infektionen durch resistente Infektionserreger
Klinische Pädiatrie 225:93-95 DOI: 10.1055/s-00000034 Language: German
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Capsular Gene Typing of Streptococcus agalactiae Compared to Serotyping by Latex Agglutination

Yao K, Poulsen K, Maione D, Rinaudo CD, Baldassarri L, Telford JL, Sørensen UBS, members of the DEVANI Study Group*, Kilian M. (* Dr. Markus Hufnagel is a contributing member of the DEVANI (Design of a Vaccine Against Neonatal Infections) Study Group.) (2013).
Capsular Gene Typing of Streptococcus agalactiae Compared to Serotyping by Latex Agglutination.
Journal of Clinical Microbiology 51(2):503-7 DOI: 10.1128/JCM.02417-12 Language: English
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Q-Fever

Bialek R, Bernard H, Hufnagel M (2013).
Q-Fever. (Q-Fieber)
Chapter(s) in "DGPI Handbuch: Infektionen bei Kindern und Jugendlichen" ("DGPI Handbook of Infectious Diseases in Children and Adolescents"), eds. Deutsche Gesellschaft für Pädiatrische Infektiologie (DGPI). Georg Thieme Verlag, Stuttgart, pp. 463-465. ISBN: 9783131447166. Language: German.
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Impact of technical training on rapid antigen detection tests (RADT) in group A streptococcal tonsillopharyngitis

Toepfner N, Henneke P, Berner R, Hufnagel M (2012).
Impact of technical training on rapid antigen detection tests (RADT) in group A streptococcal tonsillopharyngitis.
European Journal of Clinical Microbiology and Infectious Diseases 32:609-611 DOI: 10.1007/s10096-012-1783-7 Language: English
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Primary erythromalalgia in a 12-year-old boy: Positive response to sodium channel blockers despite negative SCN9A mutations

Jakob A, Creutzfeldt R, Staszewski O, Winterpacht A, Berner R, Hufnagel M (2012).
Primary erythromalalgia in a 12-year-old boy: Positive response to sodium channel blockers despite negative SCN9A mutations.
Klinische Pädiatrie 224:309–312 DOI: 10.1055/s-0031-1287823 Language: English
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2023-10-16T16:35:29+02:00Categories: Original research|Tags: |

Significant decline in the erythromycin resistance of group A streptococcus isolates at a German paediatric tertiary care centre

Farmand S, Henneke P, Hufnagel M, Berner R (2012).
Significant decline in the erythromycin resistance of group A streptococcus isolates at a German paediatric tertiary care centre.
European Journal of Clinical Microbiology and Infectious Diseases 31:707-710 DOI: 10.1007/s10096-011-1362-3 Language: English
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Prevention of group B streptococcal neonatal disease revisited: The DEVANI European Project

Rodriguez-Granger J, Alvargonzalez JC, Berardi A, Berner R, Kunze M, Hufnagel M, Melin P, Decheva A, Orefici G, Poyart C, Telford J, Efstratiou A, Killian K, Krizova P, Baldassarri L, Spellerberg S, Puertas A and Rosa-Fraile M (2012).
Prevention of group B streptococcal neonatal disease revisited: The DEVANI European Project.
European Journal of Clinical Microbiolology and Infectious Diseases 31:20972104 DOI: 10.1007/s10096-012-1559-0 Language: English
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Subtle differences in CTL cytotoxicity determine susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome

Jessen B, Maul-Pavicic A, Ufheil H, Vraetz T, Enders A, Lehmberg K, Längler A, Gross-Wieltsch U, Bay A, Kaya Z, Bryceson YT, Koscielniak E, Badawy S, Davies G, Hufnagel M, Schmitt-Gräff A, Aichele P, zur Stadt U, Schwarz K, Ehl S (2011).
Subtle differences in CTL cytotoxicity determine susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome.
Blood 118:4620-4629 DOI: 10.1182/blood-2011-05-356113 Language: English
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2023-10-15T21:38:29+02:00Categories: Original research|Tags: , |

Genetic Differences Between Invasive and Noninvasive Neonatal Group B Streptococcal Isolate

Fluegge K, Wons J, Spellerberg B, Swoboda S, Siedler A, Hufnagel M, Berner R (2011).
Genetic Differences Between Invasive and Noninvasive Neonatal Group B Streptococcal Isolate.
Pediatric Infectious Disease Journal 30:1027-1031 DOI: 10.1097/INF.0b013e31822a2a1f Language: English
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International External Quality Assurance for Laboratory Diagnosis and Typing of Streptococcus agalactiae (group B streptococci)

Afshar B, Broughton K, Creti R, Detcheva A, Hufnagel M, Kriz P, Lambertsen L, Lovgren M, Melin P, Orefici G, Poyart C, Radtke A, Rodriguez-Granger J, Skov Sørensen UB, Telford J, Valinsky L, Zachariadou L, Members of the DEVANI study group*, Efstratiou A. (* Dr. Markus Hufnagel is a contributing member of the DEVANI (Design of a Vaccine Against Neonatal Infections) Study Group.) (2011).
International External Quality Assurance for Laboratory Diagnosis and Typing of Streptococcus agalactiae (group B streptococci).
Journal of Clinical Microbiology 49:1475-1482 DOI: 10.1128/JCM.02365-10 Language: English
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Orai1 is required for target cell-induced NK cell degranulation and cytokine production

Maul-Pavicic A, Chiang S, Rensing-Ehl A, Fauriat C, Hufnagel M, Schulze I, Bass T, Schamel W, Schwarz K, Bryceson Y, Ehl S (2011).
Orai1 is required for target cell-induced NK cell degranulation and cytokine production.
Proceedings of the National Academy of Science 108:3324-3329 DOI: 10.1073/pnas.1013285108 Language: English
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2023-10-15T21:38:45+02:00Categories: Original research|Tags: , |

Pneumococcus Vaccination and Serotype Replacement: Do we need a new vaccine or vaccination concept?

2023-11-07T00:45:33+02:00Categories: Medical reviews|Tags: , , |

Japanese Encephalitis: Defining Risk Incidence for Travelers to Endemic Countries and Vaccine Prescribing From the UK and Switzerland

Hatz C, Werlein J, Mutsch M, Hufnagel M, Behrens RH (2009).
Japanese Encephalitis: Defining Risk Incidence for Travelers to Endemic Countries and Vaccine Prescribing From the UK and Switzerland.
Journal of Travel Medicine 16:200-203 DOI: 10.1111/j.1708-8305.2009.00334.x Language: English
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Successful Continuous Renal Replacement Therapy in a Neonate with Early-onset Group B Streptococcal Sepsis and Multi-organ Dysfunction Syndrome

Secular trends in pediatric bloodstream infections over a 20-year period at a tertiary care hospital in Germany

Hufnagel M, Burger A, Bartelt S, Henneke P, Berner R (2008).
Secular trends in pediatric bloodstream infections over a 20-year period at a tertiary care hospital in Germany.
European Journal of Pediatrics 167:1149-59 DOI: 10.1007/s00431-007-0651-4 Language: English
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2023-10-15T21:39:14+02:00Categories: Original research|Tags: , , |

Epidemiology of Staphylococcus aureus bacteremia in childhood – "secular trends"

Pneumococcus: The Clinical Picture

Hufnagel M (2008).
Pneumococcus: The Clinical Picture. (Pneumokokken: Das Krankheitsbild)
Chapter(s) in "Konjugatimpfstoffe und Infektionskrankheiten durch bekapselte Erreger" ("Conjugate Vaccines and Infectious Diseases Caused by Capsulated Microorganisms"), eds. Berner R. Uni-Med Science, Bremen, pp. 1:25-35. ISBN: 9783837410204. Language: German.
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Enterococcal colonization of infants in a neonatal intensive care unit: Seasonal patterns and associated risk factors

Hufnagel M, Liese C, Löscher C, Kunze K, Prömpeler H, Berner R, Krüger M (2007).
Enterococcal colonization of infants in a neonatal intensive care unit: Seasonal patterns and associated risk factors.
BMC Infectious Diseases 7:107 DOI: 10.1186/1471-2334-7-107 Language: English
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Disseminated human bocavirus infection in a child following hematopoietic stem cell transplantation

Schenk T, Strahm B, Kontny U, Hufnagel M, Neumann-Haefelin D, Falcone V (2007).
Disseminated human bocavirus infection in a child following hematopoietic stem cell transplantation.
Emerging Infectious Diseases 13:1425-1427 DOI: 10.3201/eid1309.070318 Language: English
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2023-10-15T21:40:06+02:00Categories: Original research|Tags: , , |

Distribution of four capsular serotypes of Enterococcus faecalis among clinical isolates from different geographical origins and infection sites

Hufnagel M, Carey VJ, Baldassarri L, Reinert RR, Huebner J (2006).
Distribution of four capsular serotypes of Enterococcus faecalis among clinical isolates from different geographical origins and infection sites.
Infection 34:22-25 DOI: 10.1007/s15010-006-4100-5 Language: English
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Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly

Buck D, Malivert L, de Chasseval R, Barraud A, Fondanèche M-C, Sanal O, Plebani A, Stèphan J-L, Hufnagel M, le Deist F, Fischer A, Durandy A, de Villartay JP, Revy P (2006).
Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly.
Cell 124:287-299 DOI: 10.1016/j.cell.2005.12.030 Language: English
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2023-10-15T21:40:17+02:00Categories: Original research|Tags: , |

Analysis of the specific immune response against capsular polysaccharides of two patients with systemic enterococcal infections

Naturally acquired antibodies against four Enterococcus faecalis capsular polysaccharides in normal human sera

Hufnagel M, Kropec A, Theilacker C, Huebner J (2005).
Naturally acquired antibodies against four Enterococcus faecalis capsular polysaccharides in normal human sera.
Clinical and Vaccine Immunology (formerly Clinical and Diagnostic Laboratory Immunology) 12:930-934 DOI: 10.1128/CDLI.12.8.930-934.2005 Language: English
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Serological and genetic diversity of capsular polysaccharides in Enterococcus faecalis

Hufnagel M, Hancock LE, Koch S, Theilacker C, Gilmore MS, Huebner J (2004).
Serological and genetic diversity of capsular polysaccharides in Enterococcus faecalis.
Journal of Clinical Microbiology 42:2548-2557 DOI: 10.1128/JCM.42.6.2548-2557.2004 Language: English
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A putative sugar-binding transcriptional regulator in a novel gene locus in Enterococcus faecalis contributes to biofilm formation and prolonged bacteremia in mice

Hufnagel M, Koch S, Creti R, Baldassarri L, Huebner J (2004).
A putative sugar-binding transcriptional regulator in a novel gene locus in Enterococcus faecalis contributes to biofilm formation and prolonged bacteremia in mice.
Journal of Infectious Diseases 189:420-430 DOI: 10.1086/381150 Language: English
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Opsonophagocytic assay as a potentially useful tool for assessing safety of Enterococcal preparation

Hufnagel M, Koch S, Kropec A, Huebner J (2003).
Opsonophagocytic assay as a potentially useful tool for assessing safety of Enterococcal preparation.
International Journal of Food Microbiology 88:263-267 DOI: 10.1016/s0168-1605(03)00189-2 Language: English
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A new LightCycler™ polymerase chain reaction for rapid and sensitive quantification of parvovirus B19 DNA guides therapeutic decision-making in chronic infections

Harder TC, Hufnagel M, Zahn K, Beutel K, Schmitt HJ, Ullmann U, Rautenberg P (2001).
A new LightCycler™ polymerase chain reaction for rapid and sensitive quantification of parvovirus B19 DNA guides therapeutic decision-making in chronic infections.
Journal of Clinical Microbiology 39:4413-4419 DOI: 10.1128/JCM.39.12.4413-4419.2001 Language: English
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2023-10-15T21:41:50+02:00Categories: Original research|Tags: , , |

Further evidence for a dominant form of familial persistent hyperinsulinemic hypoglycemia of infancy: a family with documented hyperinsulinemia in two generations

Hufnagel M, Eichmann D, Stieh J, Santer R (1998).
Further evidence for a dominant form of familial persistent hyperinsulinemic hypoglycemia of infancy: a family with documented hyperinsulinemia in two generations.
Journal of Clinical Endocrinology and Metabolism 83:2215-2216 DOI: 10.1210/jc.83.6.2215-a Language: English
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2023-10-15T21:42:08+02:00Categories: Original research|

Impaired macrophage listericidal and cytokine activities are responsible for the rapid death of Listeria monocytogenes-infected IFN-gamma receptor-deficient mice

Dai WJ, Bartens W, Kohler G, Hufnagel M, Kopf M, Brombacher F (1997).
Impaired macrophage listericidal and cytokine activities are responsible for the rapid death of Listeria monocytogenes-infected IFN-gamma receptor-deficient mice.
Journal of Immunology 158(11):5297-304 DOI: Language: English
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Acute renal failure without liver involvement in Leptospirosis icterohaemorrhagiae infection

Hufnagel M, Tuchelmann, Zimmerhackl LB, Leititis JU, Tüchelmann T, Brandis M, Brem S, Schindera F (1994).
Acute renal failure without liver involvement in Leptospirosis icterohaemorrhagiae infection. Akutes Nierenversagen ohne Leberbeteiligung bei Leptospira icterohaemorrhagiae-Infektion
Monatsschrift Kinderheilkunde 142:957-960 DOI: Language: German
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